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P7547

Phentolamine hydrochloride

≥98% (TLC), α-adrenoceptor antagonist, powder

Synonym(s):

2-[N-(3-Hydroxyphenyl)-p-toluidinomethyl]-2-imidazolidine hydrochloride, 3-[[(4,5-Dihydro-1H-imidazol-2-yl)-methyl](4-methylphenyl)-amino]-phenol monohydrochloride

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About This Item

Empirical Formula (Hill Notation):
C17H19N3O · HCl
CAS Number:
73-05-2
Molecular Weight:
317.81
NACRES:
NA.77
PubChem Substance ID:
24898856
UNSPSC Code:
12352116
EC Number:
200-793-5
MDL number:
MFCD00079268
Beilstein/REAXYS Number:
3764617
Assay:
≥98% (TLC)
Form:
powder
Quality level:
200

Key Documents

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Product Name

Phentolamine hydrochloride, ≥98% (TLC), powder

InChI

1S/C17H19N3O.ClH/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H

SMILES string

Cl[H].Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3

InChI key

TUEJFGFQYKDAPM-UHFFFAOYSA-N

assay

≥98% (TLC)

form

powder

color

white to off-white

solubility

ethanol: 14 mg/mL, H2O: 20 mg/mL, H2O: unstable (prepare immediately prior to use)

originator

Novartis

Quality Level

200

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

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Show Differences

1 of 4

This Item
P7561T4264SML1507
Phentolamine hydrochloride ≥98% (TLC), powder

Sigma-Aldrich

P7547

Phentolamine hydrochloride

Phentolamine methanesulfonate salt ≥98% (TLC), powder

Sigma-Aldrich

P7561

Phentolamine methanesulfonate salt

Tetrahydrozoline hydrochloride ≥98% (HPLC)

Sigma-Aldrich

T4264

Tetrahydrozoline hydrochloride

CRT0066101 hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML1507

CRT0066101 hydrochloride

form

powder

form

powder

form

-

form

powder

assay

≥98% (TLC)

assay

≥98% (TLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

solubility

ethanol: 14 mg/mL, H2O: unstable (prepare immediately prior to use), H2O: 20 mg/mL

solubility

ethanol: 26 mg/mL, H2O: 50 mg/mL

solubility

H2O: freely soluble, alcohol: freely soluble, chloroform: very slightly soluble, diethyl ether: insoluble

solubility

H2O: 15 mg/mL, clear

color

white to off-white

color

white to off-white

color

-

color

white to beige

originator

Novartis

originator

Novartis

originator

Novartis

originator

-

Biochem/physiol Actions

α-adrenoceptor antagonist; peripheral vasodilator.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

Protect From Light.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000412265
0000412265
0000322629
0000322629
0000235441

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Wei Zhang et al.
Drug discoveries & therapeutics, 8(1), 11-17 (2014-03-22)
α1-Adrenergic receptors (α1-ARs), as one of the most important members of G protein-coupled receptors (GPCRs), can mediate lots of physiological responses of the sympathetic nervous system. Until now, α1-ARs have been divided into at least three subtypes, α1A, α1B, and
Travis Alvine et al.
The Journal of experimental biology, 216(Pt 5), 751-758 (2012-11-06)
We investigated sex differences in cardiovascular maturation in embryos of the snapping turtle Chelydra serpentina, a species with temperature-dependent sex determination. One group of eggs was incubated at 26.5°C to produce males. Another group of eggs was incubated at 26.5°C
J Daniel Obray et al.
Frontiers in cellular neuroscience, 16, 944243-944243 (2022-07-30)
Dopamine (DA) is a cell-signaling molecule that does not readily cross the blood-brain barrier. Despite this, peripherally administered DA enhances DA levels in the nucleus accumbens and alters DA-related behaviors. This study was designed to investigate whether DA subtype-2 receptors
Milena Jankowska et al.
Pesticide biochemistry and physiology, 158, 101-111 (2019-08-06)
Standard chemical insecticides present mainly neurotoxic effects and are becoming less and less effective due to insects developing resistance to them. One of the innovative strategies to control insects pests is to find a way to increase the sensitivity of
Kazuhisa Honda et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 163(3-4), 260-264 (2012-08-23)
We investigated the mechanism underlying central glucagon-induced hyperglycemia and anorexia in chicks. Male 8-day-old chicks (Gallus gallus) were used in all experiments. Intracerebroventricular administration of glucagon in chicks induced hyperglycemia and anorexia from 30 min after administration. However, the plasma
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