Anti-Presenilin-1 (S182) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

MDL number:
Pricing and availability is not currently available.

biological source


antibody form

IgG fraction of antiserum

antibody product type

primary antibodies




buffered aqueous solution

species reactivity

mouse, rat, human, Xenopus


immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100 using methacarn-fixed, formic acid-treated sections of Alzheimer′s Disease (AD) brain
microarray: suitable
western blot: 1:10,000 using whole cell extract of PC12 rat adrenal pheochromocytoma cell line



UniProt accession no.

shipped in

dry ice

storage temp.


Gene Information

human ... PSEN1(5663)
mouse ... Psen1(19164)
rat ... Psen1(29192)

General description

Presenilin 1& 2 (PS1 and PS2) are highly homologous proteins (approx. 43-52 kD) with eight transmembrane domains. In the brain, PS1 and PS2 are expressed primarily in neurons and localized mainly in cell bodies, axons and dendrites. In non-neuronal cells, PS1 and PS2 are localized to the nuclear membrane, endoplasmic reticulum and Golgi. Presenilin 1 is located on chromosome 14.


Specific for presenilin 1 (not found in presenilin 2) and is identical in mouse, rat, and Xenopus. By immunoblotting, the antibody reacts with presenilin 1 (PS1, S182) and with the PS1 cleavage product.


synthetic peptide corresponding to the C-terminal of human presenilin-1 (amino acids 450-467 with N-terminally added lysine) conjugated to KLH.


Anti-Presenilin-1 (S182) antibody produced in rabbit has been used in:
  • immunostaining
  • immunofluorescence detection
  • immunohistochemistry
  • immunoblotting

Biochem/physiol Actions

The biological functions of the presenilin′s are yet unknown, but they are thought to be involved in protein trafficking. Mutations in the presenilin 1 (PS1) gene (>30 known pathogenic mutations) have been found in about half of the early-onset familial Alzheimer′s disease (FAD), while only two pathogenic mutations have been found in PS2.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
The role of presenilins in Alzheimer?s disease
Thinakaran G
The Journal of Clinical Investigation, 104(10), 1321-1327 (1999)
The presenilins
Tandon A and Fraser P
Genome Biology, 3(11) (2002)
Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria
Area-Gomez E, et al.
The American Journal of Pathology, 175(5), 1810-1816 (2009)
Silvia Di Loreto et al.
Experimental gerontology, 57, 57-65 (2014-05-20)
Although the beneficial responses induced in the central nervous system by early-initiated exercise have been broadly investigated, the effects of a chronic and moderate lately-initiated exercise on biochemical hallmarks of very early brain senescence have not been extensively studied. We...
Didier Pitsi et al.
The Journal of biological chemistry, 279(24), 25333-25338 (2004-04-17)
The cleavage of the transmembrane amyloid precursor protein (APP) by beta-secretase leaves the C-terminal fragment of APP, C99, anchored in the plasma membrane. C99 is subsequently processed by gamma-secretase, an unusual aspartyl protease activity largely dependent on presenilin (PS), generating...
Alzheimer's disease (AD) is the most common cause of dementia in the elderly and is characterized by gradual loss of cognitive functions.
Read More

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