P7877

Sigma-Aldrich

6-Phosphogluconic acid trisodium salt

≥97% (enzymatic)

Synonym(s):
D-Gluconate 6-phosphate trisodium salt
Empirical Formula (Hill Notation):
C6H10Na3O10P
CAS Number:
Molecular Weight:
342.08
Beilstein/REAXYS Number:
3814212
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

Quality Level

biological source

synthetic (organic)

assay

≥97% (enzymatic)

form

powder

Featured Industry

Agriculture

storage temp.

−20°C

SMILES string

[Na+].[Na+].[Na+].O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O

InChI

1S/C6H13O10P.3Na/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12;;;/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15);;;/q;3*+1/p-3/t2-,3-,4+,5-;;;/m1.../s1

InChI key

CBQSOSFCUWVWAQ-CXKLNRRHSA-K

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Application

6-Phosphogluconic acid has been used in a study to assess a spectrophotometric method for the determination of creative phosphokinase and myokinase. It has also been used in a study to investigate the reversible enzymatic sythesis of diphosphopyridine nucleotide and inorganic pyrophosphate.

Packaging

100, 500 mg in poly bottle
1, 5 g in poly bottle

Biochem/physiol Actions

Phosphogluconic acid is an intermediate in the pentose phosphate pathway.

Preparation Note

Prepared by a modification of the procedure of Seegmiller, J.E., et al., J. Biol. Chem., 192, 175 (1951).

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. P7877.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

storage_class_code

13 - Non Combustible Solids

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

A spectrophotometric method for the determination of creatine phosphokinase and myokinase.
I T OLIVER
The Biochemical journal, 61(1), 116-122 (1955-09-01)
Reversible enzymatic sythesis of diphosphopyridine nucleotide and inorganic pyrophosphate
Kornberg, A.
The Journal of Biological Chemistry, 182, 779-793 (1950)
Yasaman Barekatain et al.
Communications biology, 3(1), 328-328 (2020-06-27)
Magnetic resonance (MR) spectroscopy has potential to non-invasively detect metabolites of diagnostic significance for precision oncology. Yet, many metabolites have similar chemical shifts, yielding highly convoluted 1H spectra of intact biological material and limiting diagnostic utility. Here, we show that...
Ruilong Liu et al.
Nature communications, 10(1), 991-991 (2019-03-03)
6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP+ as cofactor in the pentose phosphate pathway (PPP). 6PGD is commonly upregulated and plays important roles in many human cancers, while the mechanism underlying such roles...
Articles
The Pentose Phosphate Pathway operates in tissues that synthesize fatty acids and steroids. Learn more about the Pentose Phosphate Pathway, what it is and how it works.
Read More

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