P8629

5β-Pregnane-3α,17α,20α-triol

Name: 5β-Pregnane-3α,17α,20α-triol
Brand: SIGMA
Price: 838 USD
Availability: InStock

≥98.00% (TLC), Inactive progestrone metabolite, powder

Synonym(s):

3α,17α,20α-Trihydroxy-5β-pregnane, Pregnanetriol

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100 MG

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₃₆O₃

CAS Number:

1098-45-9

Molecular Weight:

336.51

NACRES:

NA.77

PubChem Substance ID:

24898959

UNSPSC Code:

12352202

EC Number:

214-148-0

MDL number:

MFCD00003678

Beilstein/REAXYS Number:

2619975

Assay:

≥98.00% (TLC)

Form:

powder

Quality level:

200

Key Documents

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Product Name

5β-Pregnane-3α,17α,20α-triol,

InChI

1S/C21H36O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h13-18,22-24H,4-12H2,1-3H3/t13-,14+,15+,16+,17-,18-,19-,20-,21-/m0/s1

InChI key

SCPADBBISMMJAW-UHHUKTEYSA-N

SMILES string

[H][C@]12CC[C@]3([H])[C@]([H])(CC[C@@]4(C)[C@@]3([H])CC[C@]4(O)[C@H](C)O)[C@@]1(C)CC[C@@H](O)C2

assay

≥98.00% (TLC)

form

powder

solubility

chloroform: methanol (1:1): 19.60-20.40 mg/mL, clear, colorless

shipped in

ambient

storage temp.

room temp

Quality Level

200

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Show Differences

1 of 4

This Item	P8129	P0543	P2016
Sigma-Aldrich P8629 5β-Pregnane-3α,17α,20α-triol	Sigma-Aldrich P8129 5β-Pregnan-3α-ol-20-one	Sigma-Aldrich P0543 5-Pregnen-3β-ol-20-one-16α-carbonitrile	Sigma-Aldrich P2016 3α,21-Dihydroxy-5α-pregnan-20-one
form powder	form powder	form powder, crystals or chunks	form powder
assay ≥98.00% (TLC)	assay ≥98% (TLC)	assay ≥97%	assay ≥95%
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 200
storage temp. room temp	storage temp. room temp	storage temp. 2-8°C	storage temp. -
solubility chloroform: methanol (1:1): 19.60-20.40 mg/mL, clear, colorless	solubility chloroform: 50 mg/mL, clear, colorless	solubility chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow (with heat)	solubility -
shipped in ambient	shipped in ambient	shipped in ambient	shipped in -

Biochem/physiol Actions

5β-Pregnane-3α,17α,20α-triol (pregnanetriol) plays a role in the synthesis of adrenal corticoids. Levels of pregnanetriol are elevated in the urine of 21-hydroxylase deficiency and congenital adrenal hyperplasia (CAH) patients.

General description

5β-Pregnane-3α,17α,20α-triol (pregnanetriol) is a urinary steroid metabolite of 17α-hydroxyprogesterone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Synthesis of 20 alpha-hydroxylated steroids by ovaries of the dab (Limanda limanda).

A V Canario et al.

General and comparative endocrinology, 76(1), 147-158 (1989-10-01)

Dab (Limanda limanda) ovarian fragments were incubated in vitro with either [4,7-3H]pregnenolone or 17 alpha-hydroxy[1,2,6,7-3H]progesterone to investigate the pattern of steroidogenesis. A major enzyme found in the dab ovary was 20 alpha-hydroxysteroid dehydrogenase. Among the steroids that were tentatively identified

Levels of 17 alpha,20 alpha-dihydroxy-4-pregnen-3-one, 3 beta,17 alpha,20 alpha-trihydroxy-5 beta-pregnane, and other sex steroids, in blood plasma of male dab, Limanda limanda (marine flatfish) injected with human chorionic gonadotrophin.

A V Canario et al.

General and comparative endocrinology, 83(2), 258-264 (1991-08-01)

In a previous study, plasma sex steroid levels were measured in female dab (Limanda limanda) induced to ovulate by injections of human chorionic gonadotrophin (HCG). In the present study, a similar experiment was carried out on male dabs. In common

Dynamic analysis of human small intestinal microbiota after an ingestion of fermented milk by small-intestinal fluid perfusion using an endoscopic retrograde bowel insertion technique.

Toshihiko Takada et al.

Gut microbes, 11(6), 1662-1676 (2020-06-20)

Probiotic products have been shown to have beneficial effects on human hosts, but what happens in the gastrointestinal tract after its ingestion remains unclear. Our aim was to investigate the changes within the small intestines after a single intake of

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5β-Pregnane-3α,17α,20α-triol