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P8783

Sigma-Aldrich

Progesterone

powder, BioReagent, suitable for cell culture

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Synonym(s):
4-Pregnene-3,20-dione
Empirical Formula (Hill Notation):
C21H30O2
CAS Number:
Molecular Weight:
314.46
Beilstein:
1915950
EC Number:
MDL number:
PubChem Substance ID:

biological source

synthetic (organic)

Quality Level

description

synthesized from materials derived from plant source

product line

BioReagent

Assay

≥99%

form

powder

potency

0.1-20 ng/mL

technique(s)

cell culture | mammalian: suitable

mp

128-132 °C (lit.)

solubility

absolute ethanol: 1 mg/mL

storage temp.

room temp

SMILES string

CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1

InChI key

RJKFOVLPORLFTN-LEKSSAKUSA-N

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1 of 4

This Item
P6149P0130P3972
Progesterone powder, BioReagent, suitable for cell culture

Sigma-Aldrich

P8783

Progesterone

Progesterone γ-irradiated, BioXtra, suitable for cell culture

Sigma-Aldrich

P6149

Progesterone

Progesterone ≥99%

Sigma-Aldrich

P0130

Progesterone

Progesterone meets USP testing specifications

Sigma-Aldrich

P3972

Progesterone

product line

BioReagent

product line

BioXtra

product line

-

product line

-

assay

≥99%

assay

≥99%

assay

≥99%

assay

≥97%

form

powder

form

powder

form

powder

form

solid

potency

0.1-20 ng/mL

potency

0.1-20 ng/mL

potency

-

potency

-

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

-

General description

Progesterone is a steroid hormone secreted by the ovaries.

Application

Progesterone has been used:
  • as a growth-promoting hormone in basal medium for bovine mammary epithelial cell culture
  • to test its neuroprotective abilities in a well-characterized lateral cortical contusion injury (CCI) model
  • as an endocytosis inhibitor to study its effect on Coxsackievirus A9 infection on A549 cells

Use in cell culture applications to study sterol regulation of cell signaling and gene expression.

Biochem/physiol Actions

Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.
Progesterone is a hormone that maintains pregnancy. It is essential for embryo formation, development and survival in almost all mammals. This hormone exhibits its action via progesterone receptor, which is specifically expressed in the endometrial stroma throughout pregnancy. It is known to prevent preterm delivery, when administered intramuscularly. Progesterone also controls gonadotropin secretion, activates sexual behavior and triggers ovarian events leading to ovulation. It stimulates the growth and differentiation of the uterus and prevents uterine contractility.

Other Notes

Steroid hormone produced by the corpus luteum.

Physical form

powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw

Reconstitution

To prepare 20μg/ml stock solution, add 1ml absolute ethanol per mg progesterone, gently swirl to dissolve, add 49ml sterile medium per ml ethanol.

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Carc. 2 - Lact. - Repr. 1A

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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25G
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Peroxisome proliferator-activated receptor-? activation and long-chain fatty acids alter lipogenic gene networks in bovine mammary epithelial cells to various extents
A.K.G.Kadegowda, et al.
Journal of Dairy Science, 92, 276-4289 (2009)
Neonatal progesterone programs adult uterine responses to progesterone and susceptibility to uterine dysfunction
Dhakal P, et al.
Endocrinology, 156(10), 3791-3803 (2015)
Internalization of coxsackievirus A9 is mediated by beta2-microglobulin, dynamin, and Arf6 but not by caveolin-1 or clathrin
Heikkila O, et al.
Journal of Virology, 84(7), 3666-3681 (2010)
Efficacy of progesterone following a moderate unilateral cortical contusion injury
Gilmer LK, et al.
Journal of Neurotrauma, 25(6), 593-602 (2008)
Biology of progesterone action during pregnancy recognition and maintenance of pregnancy.
Spencer T. E. and F. W. Bazer
Frontiers in Bioscience, 838, d1879-d1898 (2002)

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