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P9180

Sigma-Aldrich

Procaterol hydrochloride

β2 adrenoceptor agonist, powder

Synonym(s):

erythro-8-Hydroxy-5-[1-hydroxy-2-(isopropylamino)butyl]-2(1H)-quinolinone

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10 MG
$198.00

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About This Item

Empirical Formula (Hill Notation):
C16H22N2O3 · HCl
CAS Number:
62929-91-3
Molecular Weight:
326.82
EC Number:
263-763-0
MDL number:
MFCD04221378
UNSPSC Code:
12352202
PubChem Substance ID:
24899017
NACRES:
NA.77

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Product Name

Procaterol hydrochloride,

form

powder

Quality Level

200

storage temp.

2-8°C

SMILES string

Cl.CC[C@H](NC(C)C)[C@H](O)c1ccc(O)c2NC(=O)C=Cc12

InChI

1S/C16H22N2O3.ClH/c1-4-12(17-9(2)3)16(21)11-5-7-13(19)15-10(11)6-8-14(20)18-15;/h5-9,12,16-17,19,21H,4H2,1-3H3,(H,18,20);1H/t12-,16+;/m0./s1

InChI key

AEQDBKHAAWUCMT-CVHDTDHSSA-N

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Procaterol hydrochloride

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Sigma-Aldrich

P0884

(±)-Propranolol hydrochloride

Bepristat 2a hydrochloride ≥95% (HPLC)

Sigma-Aldrich

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Bepristat 2a hydrochloride

form

powder

form

powder

form

powder

form

powder

Quality Level

200

Quality Level

100

Quality Level

200

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

General description

Procaterol is used to prevent lung fibroblast migration.[1] It has anti-inflammatory properties. It can block type 2 T helper (Th2)-related chemokine production in human monocytes and bronchial epithelial cells.[2]

Biochem/physiol Actions

β2-adrenoceptor agonist; bronchodilator.

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCBZ8090
BCBN8424V
BCBJ5050V
1399480V
1399034

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Immune System Diseases: New Insights for the Healthcare Professional (2012)
Nobuyo Komatani-Tamiya et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 29(3-4), 511-522 (2012-04-18)
The beating cilia play a key role in lung mucociliary transport. The ciliary beating frequency (CBF) and ciliary bend amplitude (CBA) of isolated mouse bronchiolar ciliary cells were measured using a light microscope equipped with a high-speed camera (500 Hz).
Ching-Hua Huang et al.
Pediatric pulmonology, 45(10), 977-984 (2010-07-31)
Procaterol is a β2-adrenoceptor agonist used as a bronchodilator for the treatment of asthma; it also possesses an anti-inflammatory property. As chemokines play a pivotal role in inflammation and the pathogenesis of asthma, we investigated the effects of procaterol on
Y Yamazaki et al.
British journal of pharmacology, 124(3), 593-599 (1998-07-01)
1. The beta-adrenoceptor (beta-AR) subtypes mediating relaxation of the rabbit, rat and canine detrusors were subjected to functional investigation using selective beta-AR agonists and antagonists. 2. In all three species, isoprenaline, noradrenaline and adrenaline each produced a concentration-dependent relaxation of
Tadashi Kohyama et al.
Inflammation, 32(6), 387-392 (2009-09-04)
Fibroblasts are important cells that are involved in modulation of fibrosis after injuries. In some uncontrollable inflammatory processes, excess fibroblasts migrate around the small airway. The pathogenesis of chronic obstructive pulmonary disease is related to fibrosis around the small airways.
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