MilliporeSigma
All Photos(1)

Documents

P9864

Sigma-Aldrich

PTP-β human

≥90%, recombinant, expressed in E. coli K12, GST-tagged, buffered aqueous glycerol solution, ≥50,000 units/mg protein

Sign Into View Organizational & Contract Pricing

Synonym(s):
Protein Tyrosine Phosphatase-β
CAS Number:
MDL number:
NACRES:
NA.32

biological source

human

Quality Level

recombinant

expressed in E. coli K12

Assay

≥90%

form

buffered aqueous glycerol solution

specific activity

≥50,000 units/mg protein

mol wt

~250 kDa

UniProt accession no.

application(s)

cell analysis

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PTPRB(5787)

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
SRP0208SRP0220SRP0219
Sigma-Aldrich

Sigma-Aldrich

P9864

PTP-β human

Sigma-Aldrich

Sigma-Aldrich

SRP0220

DEP1 Active human

Sigma-Aldrich

Sigma-Aldrich

SRP0219

CD45 Active human

recombinant

expressed in E. coli K12

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

expressed in baculovirus infected insect cells

assay

≥90%

assay

≥90% (SDS-PAGE)

assay

≥90% (SDS-PAGE)

assay

≥90% (SDS-PAGE)

form

buffered aqueous glycerol solution

form

aqueous solution

form

aqueous solution

form

aqueous solution

specific activity

≥50,000 units/mg protein

specific activity

-

specific activity

-

specific activity

-

mol wt

~250 kDa

mol wt

19.8 kDa

mol wt

58.9 kDa

mol wt

75 kDa

General description

Protein tyrosine phosphatase, receptor type B (PTPRB), also known as vascular endothelial-protein-tyrosine phosphatase (VE-PTP), might have a role in remodeling of blood vessels and in angiogenesis. The gene encoding it is localized on human chromosome 12q15. It is also important for endothelial cell migration. The protein also controls the phosphorylation state of the angiopoietin receptor, Tie-2. PTPRB may modulate sodium channels by influencing the tyrosine phosphorylation status.

Biochem/physiol Actions

Dephosphorylates tyrosine proteins.

Unit Definition

One unit of PTP-β will hydrolyze 1.0 nanomole of p-nitrophenyl phosphate per min at 30 °C.

Physical form

solution in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCL, 3 mM DTT, 16 mM glutathione and 20% glycerol

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Prioritization of Schizophrenia Risk Genes
by a Network-Regularized Logistic
Regression Method
Wen Zhang
INTERNATIONAL CONFERENCE OF COMPUTATIONAL METHODS IN SCIENCES AND ENGINEERING 2009:(ICCMSE 2009). (2016)
Picomolar concentrations of free zinc(II) ions regulate receptor protein-tyrosine phosphatase ? activity.
Wilson M
The Journal of Biological Chemistry (2012)
1002 protein phosphatases?
H Charbonneau et al.
Annual review of cell biology, 8, 463-493 (1992-01-01)
A sodium channel signaling complex: modulation by associated receptor protein tyrosine phosphatase beta.
Ratcliffe CF
Nature Neuroscience (2000)
Shear stress-induced redistribution of vascular endothelial-protein-tyrosine phosphatase (VE-PTP) in endothelial cells and its role in cell elongation.
Mantilidewi KI
The Journal of Biological Chemistry (2014)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service