All Photos(1)

PLA0011

Sigma-Aldrich

Rabbit anti-DNMT1 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):
DNA MTase HsaI, CXXC-type zinc finger protein 9, DNA methyltransferase HsaI, MCMT, ADCADN, AIM, Dnmt1, HSN1E, CXXC9, DNMT, m.HsaI
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

Powered by Bethyl Laboratories, Inc.

species reactivity

human

application(s)

immunoprecipitation (IP): 2-4 μg/mg
western blot: 1:2000-1:10,000

accession no.

NP_001370.1

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

Gene Information

rabbit ... DNMT1(1786)

Immunogen

The epitope recognized by PLA0011 maps to a region between residue 700 and 750 of human DNA-Methyltranserase 1 using the numbering given in entry NP_001370.1 (GeneID 1786).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide

Other Notes

DNA methyltransferase 1 (DNMT1) catalyzes the methylation of the 5′-cytosine in the dinucleotide sequence, CpG. DNMT1 is thought to be responsible for the regulation of methylation patterns that are important in development and influence gene expression in a time- and tissue-specific manner.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids

WGK Germany

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

TGF-I?-induced epigenetic deregulation of SOCS3 facilitates STAT3 signaling to promote fibrosis.
Dees, et al.
The Journal of Clinical Investigation, 130, 2347-2363 (2021)
Ming Li et al.
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 26(4), 371-381 (2014-09-19)
To better understand the contribution of dysregulated DNA methyltransferase 1 (DNMT1) expression to the progression and biology of clear cell renal cell carcinoma (ccRCC). We examined the differences in the expression of DNMT1 in 89 ccRCC and 22 normal tissue...
Carlos Alberto Valencia Antúnez et al.
Oncology reports, 32(5), 2093-2103 (2014-09-06)
Carcinogenesis is driven by the accumulation of mutations and abnormal DNA methylation patterns, particularly the hypermethylation of tumor‑suppressor genes. Changes in genomic DNA methylation patterns are established by the DNA methyltransferases (DNMTs) family: DNMT1, DNMT3a and DNMT3b. The DNMTs are...
Mina Sasaki et al.
Biochemical and biophysical research communications, 452(3), 622-628 (2014-09-03)
Reactive oxygen species (ROS) can cause severe damage to DNA, proteins and lipids in normal cells, contributing to carcinogenesis and various pathological conditions. While cellular senescence arrests the early phase of cell cycle without any detectable telomere loss or dysfunction....
Haiyan Huang et al.
Biochemical and biophysical research communications, 452(3), 708-714 (2014-09-10)
Benzo(a)pyrene (BaP) is a known carcinogen cytotoxic which can trigger extensive cellular responses. Many evidences suggest that inhibitors of poly(ADP-ribose) glycohydrolase (PARG) are potent anticancer drug candidates. However, the role of PARG in BaP carcinogenesis is less understood. Here we...

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service