PLA0061

Sigma-Aldrich

Rabbit anti-MCM3 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):
beta subunit, RLFB, P1.h, cervical cancer proto-oncogene 5, minichromosome maintenance deficient (S. cerevisiae) 3, DNA replication factor MCM3, MCM3 minichromosome maintenance deficient 3, MCM3 minichromosome maintenance deficient 3 (S. cerevisiae), HCC5, p102, DNA polymerase alpha holoenzyme-associated protein P1, RLF subunit beta, P1-MCM3, hRlf beta subunit, minichromosome maintenance deficient 3, replication licensing factor
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

Powered by Bethyl Laboratories, Inc.

species reactivity

human

application(s)

immunohistochemistry: 1:1,000-1:5,000
immunoprecipitation (IP): 2- 5 μg/mg
western blot: 1:2,000- 1:10,000

accession no.

NP_002379.2

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

Gene Information

rabbit ... MCM3(4172)

Immunogen

The epitope recognized by PLA0061 maps to a region between residues 500 and 550 of human Minichromosome Maintenance 3 using the numbering given in entry NP_002379.2 (GeneID 4172).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

The MCM (Mini-Chromosome Maintenance) complex is a key component of the pre-replication complex involved in replication licensing which restricts DNA replication to only once per cell cycle. The MCM complex is a heterohexamer of MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7. MCM3 has been shown to interact with MCM5, CDC46, and the acetyltransferase MCM3AP.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

RIDADR

NONH for all modes of transport

WGK Germany

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Kyle P Heim et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(44), 15746-15751 (2014-10-22)
The cariogenic bacterium Streptococcus mutans uses adhesin P1 to adhere to tooth surfaces, extracellular matrix components, and other bacteria. A composite model of P1 based on partial crystal structures revealed an unusual complex architecture in which the protein forms an...
Tatiana Pochechueva et al.
Journal of immunological methods, 412, 42-52 (2014-07-06)
Glycan-based suspension array (SGA) is an "in-house" developed multi-target immunoassay, employing commercially available fluorescent microbeads as a solid support for unique chemically synthesized glycopolymers which capture naturally occurring human anti-glycan antibodies. SGA is a sensitive and reliable tool for the...

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