PLA0064

Sigma-Aldrich

Rabbit anti-MCM5 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):
CDC46, MCM5 minichromosome maintenance deficient 5, CDC46 homolog, cell division cycle 46 (S. cerevisiae), P1-CDC46, minichromosome maintenance deficient (S. cerevisiae) 5 (cell division cycle 46), cell division cycle 46, minichromosome maintenance deficient 5 (cell division cycle 46)
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

Powered by Bethyl Laboratories, Inc.

species reactivity

mouse, human

application(s)

immunohistochemistry: 1:500- 1:2,000
immunoprecipitation (IP): 2- 4 μg/mg
western blot: 1:5,000-1:20,000

accession no.

NP_006730.2

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

Gene Information

rabbit ... MCM5(4174)

Immunogen

The epitope recognized by PLA0064 maps to a region between residues 1 and 50 of human Minichromosome Maintenance 5 using the numbering given in entry NP_006730.2 (GeneID 4174).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide

Other Notes

The MCM (Mini-Chromosome Maintenance) complex is a key component of the pre-replication complex involved in replication licensing which restricts DNA replication to only once per cell cycle. The MCM complex is a heterohexamer of MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7. MCM5 can form a subcomplex with MCM3. MCM5 also appears to play a role in transcription. MCM5 has been shown to interact with the signal transducer and activator of transcription 1 (STAT1) and demonstrated to be essential for STAT1 target gene transcription.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

RIDADR

NONH for all modes of transport

WGK Germany

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Maïté Leturcq et al.
Cellular and molecular life sciences : CMLS, 75(23), 4321-4339 (2018-08-03)
O-GlcNAcylation of proteins is governed by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). The homeostasis of O-GlcNAc cycling is regulated during cell cycle progression and is essential for proper cellular division. We previously reported the O-GlcNAcylation of the minichromosome maintenance proteins...

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