PLA0100

Sigma-Aldrich

Rabbit anti-MLL1 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):
TRX1, TET1-MLL, HRX, MLL/ENL fusion protein, MLL, MLL-AF9, mixed lineage leukemia 1, trithorax-like protein, CDK6/MLL fusion protein, zinc finger protein HRX, Myeloid/lymphoid or mixed-lineage leukemia, CXXC7, WDSTS, lysine N-methyltransferase 2A, rearranged MLL protein, HTRX1, MLL/GAS7 fusion protein, MLL1A, CXXC-type zinc finger protein 7, MLL-AF4 der(11) fusion protein, MLL/hCDCrel fusion protein, ALL-1, MLL/GAS7, lysine (K)-specific methyltransferase 2A, MLL1, MLL/GMPS fusion protein

biological source

rabbit

Quality Level

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

Powered by Bethyl Laboratories, Inc.

species reactivity

human

application(s)

ChIP: 1- 5 μg
immunoprecipitation (IP): 2-5 μg/mg
western blot: 1:2,000-1:10,000

accession no.

Q03164

shipped in

wet ice

storage temp.

2-8°C

Gene Information

rabbit ... MLL1(4297)

General description

MLL1 (mixed-lineage leukemia) gene is also referred as KMT2A (lysine methyltransferase 2A) and is located on human chromosome locus 11q23.3.

Immunogen

The epitope recognized by PLA0100 maps to a region between residues 2725 and 2775 of human myeloid/lymphoid or mixed-lineage leukemia 1 using the number given in Swiss-Prot entry Q03164 (GeneID 4297).

Biochem/physiol Actions

MLL1 (mixed-lineage leukemia) is a histone methyltransferase and has a role in embryogenesis and hematopoiesis. MLL1 is a transcriptional co-activator and regulates epigenetic gene expression through chromatin modification. MLL1 is associated with NF-κB (nuclear factor kappa B) pathway- induced brain tumor proliferation. On the other hand, MLL1 is known to prevent metastasis and invasion in cervical cancer.

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

MLL1 (mixed lineage leukemia 1) has been found to participate in a multitude of chromosomal translocations that are associated with a variety of hematologic malignancies. MLL1 functions as a transcriptional regulator and plays and important role in HOX gene expression during embryonic development.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

RIDADR

NONH for all modes of transport

WGK Germany

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
The Cks1/Cks2 axis fine-tunes Mll1 expression and is crucial for MLL-rearranged leukaemia cell viability.
Grey W, et al.
Biochimica et Biophysica Acta, 1865(1), 105-116 (2018)
KMT2A promotes melanoma cell growth by targeting hTERT signaling pathway.
Zhang C, et al.
Cell Death & Disease, 8(7), e2940-e2940 (2017)
Disease Characteristics and Prognostic Implications of Cell-Surface FLT3 Receptor (CD135) Expression in Pediatric Acute Myeloid Leukemia: A Report from the Children's Oncology Group.
Tarlock K, et al.
Clinical Cancer Research, 23(14), 3649-3656 (2017)
Ryan N Delgado et al.
Science (New York, N.Y.), 368(6486), 48-53 (2020-04-04)
Neural stem cells (NSCs) in the developing and postnatal brain have distinct positional identities that dictate the types of neurons they generate. Although morphogens initially establish NSC positional identity in the neural tube, it is unclear how such regional differences...
Xiaoqing Zeng et al.
Biochemical and biophysical research communications, 512(1), 131-136 (2019-03-16)
The prognosis of gastric cancer (GC) remains poor due to local invasion and distal metastasis. The GC-related molecular mechanisms underlying invasion and metastasis are not well understood. In this study, we investigated the functional role of ANO1 in GC progression....

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