PLA0173

Sigma-Aldrich

Rabbit anti-CDC20 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):
homolog), CDC20A, cell division cycle 20 homolog, bA276H19.3, p55CDC, CDC20 cell division cycle 20 homolog, cell division cycle 20 homolog (S. cerevisiae), CDC20 cell division cycle 20 homolog (S. cerevisiae), CDC20 (cell division cycle 20, S. cerevisiae
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

Powered by Bethyl Laboratories, Inc.

species reactivity

human, mouse

application(s)

immunohistochemistry: 1:500- 1:2,000
immunoprecipitation (IP): 2-10 μg/mg
western blot: 1:2,000- 1:10,000

accession no.

NP_001246.2

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

Gene Information

rabbit ... CDC20(991)

Immunogen

The epitope recognized by PLA0173 maps to a region between residue 449 and 499 of human cell division cycle 20 using the numbering given in entry NP_001246.2 (GeneID 991).

Physical form

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

Other Notes

CDC20 is a WD repeat containing cell cycle-regulator that binds to and activates the ubiquitin-ligase activity of the APC/c (anaphase-promoting complex/cyclosome). APC/c ubiquitinating activity is responsible for the degradation of securin and cyclin B that prompts the onset of anaphase and exit from mitosis. CDC20 has also been reported to form a complex with histone deacetylases and can function as a transcriptional repressor involved in cell cycle arrest. As a regulator of APC/c activity, CDC20 plays a key role in the spindle-assembly checkpoint.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

RIDADR

NONH for all modes of transport

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Patrícia M A Silva et al.
FEBS letters, 588(17), 3265-3273 (2014-07-30)
A predominant mechanism of spindle assembly checkpoint (SAC) silencing is dynein-mediated transport of certain kinetochore proteins along microtubules. There are still conflicting data as to which SAC proteins are dynein cargoes. Using two ATP reduction assays, we found that the...

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