PRS1112
Anti-CCR5 antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
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Synonym(s):
Anti-Chemokine (C-C motif) receptor 5
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 39 kDa
species reactivity
human
technique(s)
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CCR5(1234)
General description
C-C motif chemokine receptor 5 (CCR5) is expressed by T lymphocytes, macrophages and monocytes. It belongs to the chemokine receptor family. The gene encoding this protein is localized on human chromosome 3p21.31.
Immunogen
a peptide corresponding to amino acids 6-20 of human CCR5.
Biochem/physiol Actions
C-C motif chemokine receptor 5 (CCR5) is a receptor for chemokine ligands-3, -4 and -5. It acts as a co-receptor for human immunodeficiency virus (HIV) entry in cells.The protein also has a role in leukocyte chemotaxis. CCR5 indirectly influence the aggregation of immune cells at the site of viral infection on mucosal surfaces. It also modulates activation of immune cells during inflammation.
Linkage
The action of this antibody can be blocked using blocking peptide SBP1112.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
related product
Product No.
Description
Pricing
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Genetic Susceptibility to Cardiac and Digestive Clinical Forms of Chronic Chagas Disease: Involvement of the CCR5 59029 A/G Polymorphism
Amanda Priscila
PLoS ONE, 10(11), e0141847-e0141847 (2015)
CC chemokine receptor 5 ?32 polymorphism: association analysis and allele distribution among cutaneous leishmaniasis patients from Pakistan.
Sophie M
Journal of Cutaneous Pathology, 43(7), 564-570 (2016)
Expression cloning of new receptors used by simian and human immunodeficiency viruses
Hongkui Deng
Nature, 296-300 (1997)
The expression of the chemokine receptor CCR5 in tick-borne encephalitis
Sambor Grygorczuk
Journal of Neuroinflammation, 13, 45-45 (2016)
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