PRS2247

Sigma-Aldrich

Anti-BACE2 (ab1) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):
Anti-Asp2, Anti-β-site APP-cleaving enzyme 2
MDL number:
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 57 kDa

species reactivity

human, mouse, rat

application(s)

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

conjugate

unconjugated

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... BACE2(25825)

General description

β-site amyloid precursor protein- cleaving enzyme 2 (BACE2) is a glycoprotein which is part of the transmembrane aspartic protease family. The gene encoding this protein is localized on human chromosome 21q22.3.

Immunogen

a synthetic peptide corresponding to amino acids 44-59 of human BACE2.

Biochem/physiol Actions

β-site amyloid precursor protein- cleaving enzyme 2 (BACE2) has a role in the non-amyloidogenic processing of amyloid precursor protein. It also possesses an amyloid β-degrading protease activity. Cells of individuals with Down′s syndrome show an enhanced expression of BACE1 mRNA and the protein.

Linkage

The action of this antibody can be blocked using blocking peptide SBP2247.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
BACE2 plays a role in the insulin receptor trafficking in pancreatic ?-cells
silvia Casas
The American Journal of Physiology (2010)
Characterization of a mouse model overexpressing beta-site APP-cleaving enzyme 2 reveals a new role for BACE2
Azkona G
Genes, Brain, and Behavior (2009)
Identification of BACE2 as an avid ?-amyloid-degrading protease
Samer O Abdul
Molecular Neurobiology (2012)
The proteins BACE1 and BACE2 and ?-secretase activity in normal and Alzheimer's disease brain
J. H. Stockley
Biochemical Society Transactions (2007)

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