β-site amyloid precursor protein- cleaving enzyme 2 (BACE2) is a glycoprotein which is part of the transmembrane aspartic protease family. The gene encoding this protein is localized on human chromosome 21q22.3.
a synthetic peptide corresponding to amino acids 44-59 of human BACE2.
β-site amyloid precursor protein- cleaving enzyme 2 (BACE2) has a role in the non-amyloidogenic processing of amyloid precursor protein. It also possesses an amyloid β-degrading protease activity. Cells of individuals with Down′s syndrome show an enhanced expression of BACE1 mRNA and the protein.
The action of this antibody can be blocked using blocking peptide SBP2247.
Solution in phosphate buffered saline containing 0.02% sodium azide
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