PRS3363

Sigma-Aldrich

Anti-ST2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):
Anti-Interleukin 1 receptor-like 1
MDL number:
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, mouse

application(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

conjugate

unconjugated

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

mouse ... Il1rl1(17082)

General description

ST2 (suppression of tumorigenicity) belongs to the IL-1 family of cytokines. It is also known as IL-33 (interleukin 33) and IL1RL1 (interleukin 1 receptor like 1). It is expressed in macrophages and various inflammatory cells like T helper 2 (Th2), mast cells, basophils and eosinophils. It is mapped to chromosome 2q12.

Immunogen

a synthetic peptide corresponding to 16 amino acids at the amino-terminus of mouse ST2. This peptide is common to all three known ST2 isoforms.

Application

Anti-ST2 has been used in immunohistochemistry, western blottingand immunofluorescence staining.

Biochem/physiol Actions

ST2 (suppression of tumorigenicity) participates in pathophysiology of several diseases like asthma, arthritis, obesity and atherosclerosis. It works as a mitogen in eosinophils, fibrocytes, endothelial cells. It helps in the migration of Th2 lymphocytes, fibrocytes and endothelial cells, and disturbs the incursion and metastasis of breast tumor.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3363.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

storage_class_code

12 - Non Combustible Liquids

WGK Germany

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Interleukina?`33 expression in ovarian cancer and its possible suppression of peritoneal carcinomatosis.
Sekiya, et al.
International Journal of Oncology, 55, 755-765 (2020)
Xiao-Hui Wang et al.
Molecular medicine reports, 16(4), 3887-3893 (2017-08-03)
Interleukin-33 (IL-33) promotes migration of cancer cells through downregulating the expression of E-cadherin. Previous studies have demonstrated that IL‑33 stimulates the proliferation of trophoblasts. However, the effect of IL‑33 on the adhesion and invasion of trophoblasts has not been investigated...
Mark Barbour et al.
Journal of neuroimmunology, 318, 87-96 (2018-03-13)
Experimental autoimmune encephalomyelitis (EAE) mice were administered with murine anti-CD52 antibody to investigate its therapeutic effect and whether the treatment modulates IL-33 and ST2 expression. EAE severity and central nervous system (CNS) inflammation were reduced following the treatment, which was...
Mamdouh A K Sedhom et al.
Gut, 62(12), 1714-1723 (2012-11-23)
Inflammatory bowel diseases (IBD) have been intrinsically linked to a deregulated cytokine network, but novel therapeutic principles are urgently needed. Here we identify the interleukin (IL)-33 and its receptor ST2 as key negative regulators of wound healing and permeability in...
Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice
Sedhom MA, et al.
Gut, 62(12), 1714-1723 (2013)

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