IL?33 restricts invasion and adhesion of trophoblast cell line JEG3 by downregulation of integrin ?4?1 and CD62L
Wang XH, et al.
Molecular Medicine Reports, 16(4), 3887-3893 (2017)
Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice
Sedhom MA, et al.
Gut, 62(12), 1714-1723 (2013)
Mamdouh A K Sedhom et al.
Gut, 62(12), 1714-1723 (2012-11-23)
Inflammatory bowel diseases (IBD) have been intrinsically linked to a deregulated cytokine network, but novel therapeutic principles are urgently needed. Here we identify the interleukin (IL)-33 and its receptor ST2 as key negative regulators of wound healing and permeability in...
Kirsten D Mertz et al.
Oncoimmunology, 5(1), e1062966-e1062966 (2016-03-05)
Colorectal cancer (CRC) develops through a multistep process and is modulated by inflammation. However, the inflammatory pathways that support intestinal tumors at different stages remain incompletely understood. Interleukin (IL)-33 signaling plays a role in intestinal inflammation, yet its contribution to...
Wen-Ting Hu et al.
Molecular human reproduction, 20(4), 358-372 (2013-12-18)
Interleukin (IL)-33, a newly described member of the IL-1 family, has been reported to facilitate primary tumor progression and metastatic dissemination. However, its biological function on decidual stromal cells (DSCs) remains unclear. In this study, we tested the hypothesis whether...