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PRS3941

Sigma-Aldrich

Anti-IRF7 (ab1) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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Synonym(s):
Anti-Interferon regulatory factor 7
MDL number:
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, rat, mouse

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IRF7(3665)

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This Item
HPA052757AV38128AV100841
biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

Gene Information

human ... IRF7(3665)

Gene Information

human ... IRF7(3665)

Gene Information

human ... IRF1(3659)

Gene Information

human ... IRF8(3394)

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

technique(s)

immunofluorescence: suitable, indirect ELISA: suitable, immunohistochemistry: suitable, western blot: suitable

technique(s)

immunofluorescence: 0.25-2 μg/mL, immunohistochemistry: 1:50-1:200

technique(s)

immunohistochemistry: suitable, western blot: suitable

technique(s)

immunohistochemistry: suitable, western blot: suitable

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General description

Interferon regulatory factor 7 (IRF7) protein, a multifunctional transcription factor, is a lymphoid-specific factor expressed in the cytoplasm in B cells, plasmacytoid dendritic cells (pDCs), and monocytes in the spleen, thymus, and peripheral blood lymphocytes. IRF7 gene is located on human chromosome 11p15.5.

Immunogen

a peptide corresponding to 14 amino acids near the carboxy-terminus of human IRF7 .

Application

Anti-IRF7 (ab1) antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

Interferon regulatory factor 7 (IRF7) protein plays a key role in regulating the type I interferon (IFN) alpha/beta (IFNα/β) responses, which are necessary to innate and adaptive immunity. Hence IRF7 is considered as the ‘master′ controller of IFN type I production. It plays a key role in priming. IRF7 can also form homodimers or heterodimers with interferon regulatory factor 5 (IRF5) to modulate target genes. It might regulate oncogenesis and apoptosis. IRF7 plays an important role in the pathogenesis of type I diabetes. It is connected to the latency of the Epstein–Barr virus (EBV).

Linkage

The action of this antibody can be blocked using blocking peptide SBP3941.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

related product

Product No.
Description
Pricing

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Andrographolide inhibits chikungunya virus infection by up-regulating host innate immune pathways
Gupta S, et al.
Asian Pacific Journal of Tropical Medicine (2018)
S Ning et al.
Genes and immunity, 12(6), 399-414 (2011-04-15)
Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein-Barr virus (EBV) infection, and has since emerged as the crucial regulator of type I interferons (IFNs) against pathogenic infections, which activate IRF7 by triggering signaling cascades from
Marijana Sekulic-Jablanovic et al.
Frontiers in cellular neuroscience, 14, 566148-566148 (2020-11-17)
Noise trauma, infection, and ototoxic drugs are frequent external causes of hearing loss. With no pharmacological treatments currently available, understanding the mechanisms and pathways leading to auditory hair cell (HC) damage and repair is crucial for identifying potential pharmacological targets.

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