PZ0021

Tigecycline hydrate

≥98% (HPLC)

• Synonym(s): Tigecyclin, 9-t-Butylglycylamido-minocycline hydrate, TBG-MINO, Tygacil
• Empirical Formula (Hill Notation): C₂₉H₃₉N₅O₈ · xH₂O
• CAS Number: 1229002-07-6
• Molecular Weight: 585.65 (anhydrous basis)
• PubChem Substance ID: 329823688
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D -175 to -205°, c = 0.15 in methanol
• manufacturer/tradename: Pfizer^®
• color: off-white to yellow-brown
• solubility: DMSO: ≥3 mg/mL (warmed)
• originator: Pfizer
• storage temp.: 2-8°C
• SMILES string: O.CN(C)[C@H]1[C@@H]2C[C@@H]3Cc4c(cc(NC(=O)CNC(C)(C)C)c(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)N(C)C
• InChI: 1S/C29H39N5O8.H2O/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36;/h10,12,14,21,31,36,38-39,42H,8-9,11H2,1-7H3,(H2,30,41)(H,32,35);1H2/t12-,14-,21-,29-;/m0./s1
• InChI key: PMPLAEFBZIFHAR-KXLOKULZSA-N

Description

General description

Tigecycline is used to treat complicated skin and skin structure infections (cSSSI) and complicated intraabdominal infections.

Application

TIGECYCLINE HYDRATE has been used:

• for antibiotic susceptibility testing
• to study its effects on multiple nonsmall cell lung cancer (NSCLC) cell lines
• to evaluate its effects on the binding of fluoroquinolones to human serum albumin
• as a standard to investigate the penetration of tigecycline into cornea, aqueous humor and vitreous humor

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Tigecycline is a broad spectrum glycylcycline antibiotic. Tigecycline is bacteriostatic, that inhibits protein synthesis by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline is active against resistant strains of gram-positive and gram-negative bacteria, avoiding the two most common mechanisms of resistance to the tetracycline antimicrobials: tetracycline efflux pump proteins and ribosomal protection proteins.

Other Notes

air sensitive

This compound was developed by Pfizer for Immunology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

Pfizer is a registered trademark of Pfizer, Inc.

Safety Information

• Pictograms: GHS07,GHS08
• Signal Word: Danger
• Hazard Statements: H319 - H360
• Precautionary Statements: P201 - P202 - P264 - P280 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Eye Irrit. 2 - Repr. 1B
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable