PZ0042

Sulopenem

≥98% (HPLC)

• Synonym(s): (5R,6S)-6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[[(1R,3S)-tetrahydro-1-oxido-3-thienyl]thio]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, CP-70429
• Empirical Formula (Hill Notation): C₁₂H₁₅NO₅S₃
• CAS Number: 120788-07-0
• Molecular Weight: 349.45
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• manufacturer/tradename: Pfizer^®
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• originator: Pfizer
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: O=C(O)C1=C(S[C@@H]2C[S@+]([O-])CC2)S[C@@]3([H])N1C([C@]3([H])[C@H](O)C)=O
• InChI: 1S/C12H15NO5S3/c1-5(14)7-9(15)13-8(11(16)17)12(20-10(7)13)19-6-2-3-21(18)4-6/h5-7,10,14H,2-4H2,1H3,(H,16,17)/t5-,6?,7+,10-,21?/m1/s1
• InChI key: FLSUCZWOEMTFAQ-JNCILSLHSA-N

Description

Biochem/physiol Actions

Sulopenem is an orally available penem antibiotic designed to treat Gram-negative multi-drug resistant infections. It can be administered as an intravenous preparation, and it is also orally available.

Sulopenem, formerly CP-70,429, is stable to renal dehydropeptidase I and hydrolytic activity of AmpC β-lactamases and extended-spectrum β-lactamases (ESBLs) that convey resistance to third-generation cephalosporins. This action of sulopenem helps to act against urgent drug-resistant antimicrobial threats, including ESBL-producing Enterobacteriaceae. Sulopenem is effective than ciprofloxacin for treating urogenital upper urinary tract infection (uUTI) in adult women due to quinolone non-susceptible pathogens.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

Pfizer is a registered trademark of Pfizer, Inc.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3