PZ0219

Sigma-Aldrich

PF-06297470

≥98% (HPLC)

Synonym(s):
1-Methyl-3-(4-methyl-3-pyridinyl)-6-(2-pyridinylmethoxy)-1H-pyrazolo[3,4-b]pyrazine
Empirical Formula (Hill Notation):
C18H16N6O
CAS Number:
Molecular Weight:
332.36
MDL number:
PubChem Substance ID:

Quality Level

assay

≥98% (HPLC)

form

powder

manufacturer/tradename

Pfizer®

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

originator

Pfizer

storage temp.

2-8°C

SMILES string

CN(N=C1C2=C(C)C=CN=C2)C3=C1N=CC(OCC4=NC=CC=C4)=N3

InChI

1S/C18H16N6O/c1-12-6-8-19-9-14(12)16-17-18(24(2)23-16)22-15(10-21-17)25-11-13-5-3-4-7-20-13/h3-10H,11H2,1-2H3

InChI key

RDLSKDOSNKLEAQ-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

PF-06297470 is a potent negative allosteric modulator of the Metabotropic Glutamate Receptor 5 (mGluR5). PF-06297470 binds to mGluR5 with a Ki of 0.9 nM. The compound PF-06297470 displays slight antagonism of mGluR1 (IC50 = 30.5 mM), with no agonist or antagonist activities against any other mGlu receptor subtype at concentrations up to 50 mM. PF-06297470 reduces dyskinesia in a rodent (MPTP)-rendered Parkinsonian model of L-DOPA-induced dyskinesia (PD-LID).

Other Notes

This compound was developed by Pfizer for Neuroscience research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

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