The solution stability is not determined. However, the literature suggests that the material is stable in solution at -80°C is for approximately 6 months; and -20°C for approximately 1 month.
PZ0233
PF-06424439
≥98% (HPLC)
Synonym(s):
[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate
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About This Item
Empirical Formula (Hill Notation):
C22H26ClN7O · CH3SO3H
CAS Number:
Molecular Weight:
536.05
UNSPSC Code:
12352200
PubChem Substance ID:
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Quality Level
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +7 to +11°, c = 1.0 in methanol
color
white to light brown
solubility
H2O: 10 mg/mL, clear
storage temp.
room temp
SMILES string
O=C([C@@H]1CCCN(C2=NC(NC(C3(CC3)N4N=CC(Cl)=C4)=N5)=C5C=C2)C1)N6CCCC6.CS(=O)(O)=O
InChI
1S/C22H26ClN7O.CH4O3S/c23-16-12-24-30(14-16)22(7-8-22)21-25-17-5-6-18(26-19(17)27-21)29-11-3-4-15(13-29)20(31)28-9-1-2-10-28;1-5(2,3)4/h5-6,12,14-15H,1-4,7-11,13H2,(H,25,26,27);1H3,(H,2,3,4)/t15-;/m1./s1
InChI key
ZSTFDNQQOJUJFL-XFULWGLBSA-N
Related Categories
1 of 4
This Item | PZ0296 | PZ0300 | PZ0324 |
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. room temp | storage temp. room temp | storage temp. room temp | storage temp. room temp |
| solubility H2O: 10 mg/mL, clear | solubility DMSO: 5 mg/mL, clear | solubility DMSO: 20 mg/mL, clear | solubility DMSO: 5 mg/mL, clear |
| color white to light brown | color white to beige | color white to beige | color white to beige |
Application
PF-06424439 has been used as a diacylglycerol acyltransferase 2 (DGAT2) inhibitor:
- to study its effects on cell mortality and lipid synthesis in epithelial colon cells and colorectal cancer stem cells[1]
- to study its effects on HeLa cells[2]
- to study its inhibitory effects on neutral lipid synthesis in HT-1080 cells[3]
Biochem/physiol Actions
PF-06424439 functions in reducing the hepatic lipid levels in dyslipidemic rats.[4]
PF-06424439 is a potent and selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2).
PF-06424439 is a potent, selective DGAT2 inhibitor.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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What is the storage temperature once reconstituted in water?
1 answer-
Helpful?
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I need the pharmacokinetics and pharmacodynamic study of PF-06424439 product, what is the half life of this DGAT 2 inhibitor please.
1 answer-
Unfortunately, pharmacokinetic, pharmacodynamic, and half-like information on this product are not available. The compound was developed by Pfizer, however, this product is intended for research use only. Some publications may be of interest.
See the link below for one such article.
https://pubs.acs.org/doi/10.1021/acs.jmedchem.5b01006#Helpful?
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Hi, I want to inquire that if the PF-06424439 product could be dissolved into DMSO? Thanks.
1 answer-
The solubility of this compound is tested in water. The use of DMSO as a solvent has not been determined. However, external sources state that PF-06424439 can be solubilized in DMSO at approximately 50 mg/mL. This information has not been verified.
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