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PZ0351

Sigma-Aldrich

PF-2545920 hydrochloride

≥97% (HPLC)

Synonym(s):
2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline hydrochloride, MP-10 hydrochloride, PF-02545920 hydrochloride, PF-920 hydrochloride
Empirical Formula (Hill Notation):
C25H20N4O · HCl
CAS Number:
Molecular Weight:
428.91
MDL number:
NACRES:
NA.77

Quality Level

Assay

≥97% (HPLC)

form

powder

manufacturer/tradename

Pfizer®

color

white to brown

solubility

DMSO: 20 mg/mL, clear

originator

Pfizer

storage temp.

room temp

SMILES string

CN1C=C(C2=CC=NC=C2)C(C(C=C3)=CC=C3OCC4=NC5=CC=CC=C5C=C4)=N1.[H]Cl

InChI

1S/C25H20N4O/c1-29-16-23(18-12-14-26-15-13-18)25(28-29)20-7-10-22(11-8-20)30-17-21-9-6-19-4-2-3-5-24(19)27-21/h2-16H,17H2,1H3

InChI key

AZEXWHKOMMASPA-UHFFFAOYSA-N

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PF-543 hydrochloride ≥98% (HPLC)

Sigma-Aldrich

PZ0234

PF-543 hydrochloride

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

manufacturer/tradename

Pfizer®

manufacturer/tradename

Pfizer®

manufacturer/tradename

Pfizer®

manufacturer/tradename

Pfizer®

color

white to brown

color

white to light brown

color

white to beige

color

white to beige

solubility

DMSO: 20 mg/mL, clear

solubility

H2O: 20 mg/mL, clear

solubility

DMSO: 5 mg/mL (clear solution, warmed)

solubility

DMSO: 20 mg/mL, clear

originator

Pfizer

originator

Pfizer

originator

Pfizer

originator

Pfizer

Biochem/physiol Actions

PF-2545920 hydrochloride (MP-10) is a potent and selective cyclic nucleotide phosphodiesterase (PDE) 10A competitive inhibitor with a reported IC50 value of 1.26 nM. PDE10A hydrolyzes both cAMP and cGMP, and is highly expressed in medium spiny neurons of the mammalian striatum and in basal ganglia areas where D1 and D2 dopamine receptors are expressed. PF-2545920 has been studied for treatment of schizophrenia and Huntington′s disease.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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