Skip to Content
MilliporeSigma

Key Documents

View All Documentation

Skip To

PZ038

PF-06928215

≥98% (HPLC)

Synonym(s):

rel-(1R,2S)2(7-Oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3 carboxamido) cyclohexane-1-carboxylic acid, rel-(1R,2S)2(7-Oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxamido)cyclohexanecarboxylic acid

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Pack SizeSKUAvailabilityPrice
5 mg
Check Cart for Availability
$116.00
$98.60
25 mg
Check Cart for Availability
$467.00

About This Item

Empirical Formula (Hill Notation):
C20H20N4O4
CAS Number:
2570808-90-9
Molecular Weight:
380.40
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD32644796
Assay:
≥98% (HPLC)
Form:
powder

$98.60

List Price$116.00Save 15%
Web-Only Promotion
Check Cart for Availability
​
Request a Bulk Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

room temp

Application

PF-06928215 has been used to study its inhibitory effects on cyclic GMP-AMP synthase (cGAS).

Biochem/physiol Actions

PF-06928215 is a high affinity (KD = 200 nM) active site-targeting, substrate-competitive cyclic GMP-AMP synthase (cGAS) inhibitor (IC50 = 4.9 μM; in the presence of 1 mM ATP, 0.3 mM GTP, 100 nM 45-bp interferon-stimulatory dsDNA (ISD)). PF-06928215 displays no inhibitory potency against dsDNA-induced IFN-β expression in cellular cGAS assays, most likely due to limited cell-permeability and/or high levels of cellular ATP and GTP in the reporter cells employed.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
PZ0357PZ0215PZ0412
PF-06928215 ≥98% (HPLC)

Sigma-Aldrich

PZ038

PF-06928215

PF-06412562 ≥98% (HPLC)

Sigma-Aldrich

PZ0357

PF-06412562

PF-04701475 ≥98% (HPLC)

Sigma-Aldrich

PZ0215

PF-04701475

PF-06427878 ≥98% (HPLC)

Sigma-Aldrich

PZ0412

PF-06427878

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 30 mg/mL, clear

solubility

DMSO: 5 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000282308
0000282309
0000231317
0000231317
0000282308

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay
Hall J, et al.
PLoS ONE, 12(9), e0184843-e0184843 (2017)
Subhadip Choudhuri et al.
PLoS pathogens, 16(4), e1008474-e1008474 (2020-04-22)
Trypanosoma cruzi (T. cruzi) is the etiological agent of Chagas cardiomyopathy. In the present study, we investigated the role of extracellular vesicles (Ev) in shaping the macrophage (Mφ) response in progressive Chagas disease (CD). We purified T. cruzi Ev (TcEv)
Structure of the human cGAS-DNA complex reveals enhanced control of immune surveillance
Zhou W, et al.
Cell, 174(2), 300-311 (2018)

Global Trade Item Number

SKUGTIN
PZ038-25MG04061835304899
PZ038-5MG04061835304905

Questions

Reviews

No rating value

Active Filters