≥95% (HPLC), solid

3,3′,4′,5,6-Pentahydroxyflavone, 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one
Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
Beilstein/REAXYS Number:
EC Number:
PubChem Substance ID:

biological source

synthetic (organic)

Quality Level


≥95% (HPLC)




316.5 °C


water: practically insoluble

storage temp.

room temp

SMILES string




InChI key


Looking for similar products? Visit Product Comparison Guide


  • Quercetin has been used as an antioxidant which reversed the immunosuppressive effects of high glucose and hyperglycemic sera in type 2 diabetic patients.
  • It has been used as a detoxifying phytochemical in Apis mellifera.
  • It has been used as a positive control in DPPH (2,2- diphenyl-1-picryhydrazyl) radical scavenging assay. It has also been used for the preparation of calibration curve to determine total flavonoid content.


10, 100 g in glass bottle

Biochem/physiol Actions

Quercetin is a flavonoid with anticancer activity. Quercetin is a mitochondrial ATPase and phosphodiesterase inhibitor. It Inhibits PI3-kinase activity and slightly inhibits PIP kinase activity. Quercetin has antiproliferative effects on cancer cell lines, reduces cancer cell growth via type II estrogen receptors, and arrests human leukemic T cells in late G1 phase of the cell cycle. Quercetin may also inhibit fatty acid synthase activity.

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound is a featured product for ADME Tox and Kinase Phosphatase research. Discover more featured ADME Tox and Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.


Skull and crossbones

Signal Word


Hazard Statements


Acute Tox. 3 Oral


6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK Germany


Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

High glucose and hyperglycemic sera from type 2 diabetic patients impair DC differentiation by inducing ROS and activating Wnt/?-catenin and p38 MAPK.
Gilardini Montani MS et al.
Biochimica et Biophysica Acta, 1862, 805-805 (2016)
Impacts of Dietary Phytochemicals in the Presence and Absence of Pesticides on Longevity of Honey Bees (Apis mellifera).
Liao LH et al.
Insects, 8, E22-E22 (2017)
Lucia Panzella et al.
Antioxidants (Basel, Switzerland), 8(4) (2019-04-04)
Exhausted woods represent a byproduct of tannin industrial production processes and their possible exploitation as a source of antioxidant compounds has remained virtually unexplored. We herein report the characterization of the antioxidant and other properties of practical interest of exhausted...
Phenolic and flavonoid content and antioxidants capacity of pressurized liquid extraction and perculation method from roots of Scutellaria pinnatifida A. Hamilt. subsp alpina (Bornm) Rech. f.
Golmakani E et al.
Journal of Supercritical Fluids, 95, 318-324 (2014)
Hubert Fleury et al.
Nature communications, 10(1), 2556-2556 (2019-06-13)
Senescence is a tumor suppression mechanism defined by stable proliferation arrest. Here we demonstrate that the known synthetic lethal interaction between poly(ADP-ribose) polymerase 1 inhibitors (PARPi) and DNA repair triggers p53-independent ovarian cancer cell senescence defined by senescence-associated phenotypic hallmarks...
Information on fatty acid synthesis and metabolism in cancer cells. Learn how proliferatively active cells require fatty acids for functions such as membrane generation, protein modification, and bioenergetic requirements. These fatty acids are derived either from dietary sources or are synthesized by the cell.
Read More
Protocol for HPLC Analysis of Flavonoids on Ascentis® RP-Amide
Read More
Related Content
Discover Bioactive Small Molecules for Kinase Phosphatase Biology
Read More
Discover Bioactive Small Molecules for ADME/Tox
Read More
Discover Bioactive Small Molecules for Lipid Signaling Research
Read More

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service