R0635

Sigma-Aldrich

Retinyl Acetate-Water Soluble

BioReagent, suitable for cell culture

Synonym(s):
Vitamin A acetate, Retinyl acetate, Retinol acetate, Vitamin A, Retinol Acetate
Empirical Formula (Hill Notation):
C22H32O2
CAS Number:
Molecular Weight:
328.49
Beilstein/REAXYS Number:
1915439
MDL number:
NACRES:
NA.75

Quality Level

biological source

synthetic (organic)

product line

BioReagent

form

powder

application(s)

cell culture | mammalian: suitable

color

white to light yellow

mp

57-58 °C

solubility

H2O: 400 mg/mL

storage temp.

−20°C

SMILES string

CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(C)=O)C(C)(C)CCC1

InChI

1S/C22H32O2/c1-17(9-7-10-18(2)14-16-24-20(4)23)12-13-21-19(3)11-8-15-22(21,5)6/h7,9-10,12-14H,8,11,15-16H2,1-6H3/b10-7+,13-12+,17-9+,18-14+

InChI key

QGNJRVVDBSJHIZ-QHLGVNSISA-N

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General description

Retinyl acetate does not exists naturally, but is derived from retinol. It is considered to be more chemically stable than retinol. For this reason it serves as a dietary supplement for vitamin A source. Vitamin A is found in food of animal origin especially liver and also present in brightly colored vegetables. Vitamin A is a member of carotene family, which is a key component in plant pigments.

Application

Use to study retinoid regulation of cell transformation; cell differentiation and stem cell development.
Retinyl Acetate-Water Soluble has been used as a component of culture medium for secretory cells of venom gland among different Viperidae snakes. It has also been used in testis chunk culturing.

Packaging

5 mg in glass bottle
Package size based on retinol acetate content

Biochem/physiol Actions

Retinyl acetate is known to prevent carcinogenic polycyclic hydrocarbon, methylcholanthrene induced morphological transformation.

Formula variant

With a minimum of 3 mg retinol acetate per gram; balance methyl-β-cyclodextrin.

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

hazcat

Repr. 1A

storage_class_code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Biological Responses in Cancer: Progress toward Potential Applications, 2, 62-62 (2013)
Long-term primary culture of secretory cells of Bothrops jararaca venom gland for venom production in vitro
Yamanouye N, et al.
Nature Protocols, 1(6), 2763-2763 (2006)
Specifications and Criteria for Biochemical Compounds, 1344, 188-188 (1967)
Advanced Nutrition Micronutrie, 23-23 (2018)
Robert E Chapin et al.
Birth defects research. Part B, Developmental and reproductive toxicology, 107(6), 225-242 (2016-12-27)
The last two decades have seen an increasing search for in vitro models that can replace the use of animals for safety testing. We adapted the methods from a recent nonquantitative report of spermatogenesis occurring in ex vivo mouse testis...

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