R0783

Sigma-Aldrich

RG-239 hydrate

Synonym(s):
(3)-3-Hydroxy-3-(2-propen-1-yl)-lup-20(29)-en-28-oic acid hydrate, (3R)-3-Allyl-3-hydroxylup-20(29)-en-28-oic acid hydrate, 18 dia 2
Empirical Formula (Hill Notation):
C33H52O3 · xH2O
Molecular Weight:
496.76 (anhydrous basis)
MDL number:
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

assay

≥98% (HPLC)

form

solid

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

O.CC(=C)[C@@H]1CC[C@@]2(CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@](O)(CC=C)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]12)C(O)=O

InChI

1S/C33H52O3.H2O/c1-9-14-33(36)20-17-29(6)24(28(33,4)5)13-15-31(8)25(29)11-10-23-26-22(21(2)3)12-16-32(26,27(34)35)19-18-30(23,31)7;/h9,22-26,36H,1-2,10-20H2,3-8H3,(H,34,35);1H2/t22-,23+,24-,25+,26+,29-,30+,31+,32-,33-;/m0./s1

Inchi Key

JMELBGCTIDKOPM-RQBNYOBGSA-N

Application

RG-239, a betulinic acid derivative and TGR5/Gpbar-1 agonist, is used to study the role of bile acid activated TGR5 in intestinal motility, inflammation, energy production, glucose homeostasis, glycemic control, obesity and liver steatosis.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Semisynthetic derivative of betulinic acid (3β-allylbetulinic acid), RG-239 is an agonist at the G-protein coupled receptor TGR5. TGR5 signalling induces glucagon-like peptide-1 (GLP-1) release in brown adipose tissue, enhancing glucose tolerance and attenuating diet-induced obesity.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin

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