R1512

Retinyl palmitate

potency: ≥1,700,000 USP units per g

• Synonym(s): Vitamin A palmitate, all−trans−Retinol palmitate
• Empirical Formula (Hill Notation): C₃₆H₆₀O₂
• CAS Number: 79-81-2
• Molecular Weight: 524.86
• Beilstein: 1917366
• EC Number: 201-228-5
• MDL number: MFCD00019414
• PubChem Substance ID: 24899347
• NACRES: NA.79

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• form: solid or viscous liquid
• potency: ≥1,700,000 USP units per g
• does not contain: antioxidant
• color: yellow to yellow-green
• mp: 26 °C
• storage temp.: 2-8°C
• SMILES string: CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(CCCCCCCCCCCCCCC)=O)C(C)(C)CCC1
• InChI: 1S/C36H60O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-25-35(37)38-30-28-32(3)23-20-22-31(2)26-27-34-33(4)24-21-29-36(34,5)6/h20,22-23,26-28H,7-19,21,24-25,29-30H2,1-6H3/b23-20+,27-26+,31-22+,32-28+
• InChI key: VYGQUTWHTHXGQB-FFHKNEKCSA-N

Description

General description

Retinyl palmitate or vitamin A palmitate is a retinoid, which is an acid form of vitamin A. Retinoids exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain. Retinyl palmitate is a major storage form of vitamin A found in epidermis. Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as needed.

Application

Retinyl palmitate has been used as a standard in high performance liquid chromatography (HPLC). It has also been used to study its effect on brain regeneration in larval Xenopus laevis.

Biochem/physiol Actions

Retinyl palmitate is widely used in pharmaceutical applications. It is also extensively used in cosmetic formulations due to its beneficial effects on the appearance of skin and anti-oxidant properties. Retinyl palmitate acts as a teratogen and affect vertebrate embryogenesis and regeneration. It is added as a source of vitamin A in low fat and skim milks. Retinyl palmitate acts as a chemopreventive or antineoplastic agent.

Review: Vitamin A metabolism.

Packaging

Sealed ampule.

Physical form

oil or solid

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H360D - H412
• Precautionary Statements: P202 - P273 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Aquatic Chronic 3 - Repr. 1B
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Flash Point(F): No data available
• Flash Point(C): No data available
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves