Documents

R2027

Sigma-Aldrich

Ral B human

recombinant, expressed in E. coli, buffered aqueous glycerol solution

MDL number:
NACRES:
NA.56
Pricing and availability is not currently available.

Quality Level

recombinant

expressed in E. coli

form

buffered aqueous glycerol solution

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... RALB(5899)

Application

Can be used as a control in immunoblotting and in protein binding assays.

Biochem/physiol Actions

Ral B has been implicated in invasion and metastasis of human cancer cells. Reports have shown that depletion of Ral B by siRNA results in significantly reduced migration rates of tumor cells, while constitutively active Ral B promoted migration.
Ral B (21 kDa, native), a member of the Ras-like GTP binding protein family, is a crucial link in intracellular signaling cascades.

Other Notes

GST-tagged Ras-like fusion protein

Physical form

Supplied as a solution in 50 mM Tris, pH 7.5, containing 150 mM sodium chloride, 10 mM magnesium chloride, 1 mM DTT, and 10% glycerol.

WGK Germany

1

Certificate of Analysis
Certificate of Origin
Gary Oxford et al.
Cancer research, 65(16), 7111-7120 (2005-08-17)
The Ral family of small G proteins has been implicated in tumorigenesis, invasion, and metastasis. However, little emphasis has been placed on clarifying the individual roles of the two Ral proteins, RalA and RalB, in these processes in view of...
Y Takai et al.
Physiological reviews, 81(1), 153-208 (2001-01-12)
Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and constitute a superfamily consisting of more than 100 members. This superfamily is structurally classified into at least five families: the Ras, Rho, Rab, Sar1/Arf, and Ran families....

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