R2153

Sigma-Aldrich

RU 26752

≥98% (HPLC), solid

Synonym(s):
17α-Hydroxy-3-oxo-7α-propylpregn-4-ene-21-carboxylic acid γ-lactone
Empirical Formula (Hill Notation):
C25H36O3
CAS Number:
Molecular Weight:
384.55
MDL number:
PubChem Substance ID:

Quality Level

assay

≥98% (HPLC)

form

solid

solubility

DMSO: soluble 20 mg/mL at 60 °C (warming up for 20 minutes)

storage temp.

−20°C

SMILES string

[H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@@]34CCC(=O)O4)[C@]1([H])[C@H](CCC)CC5=CC(=O)CC[C@]25C

InChI

1S/C25H36O3/c1-4-5-16-14-17-15-18(26)6-10-23(17,2)19-7-11-24(3)20(22(16)19)8-12-25(24)13-9-21(27)28-25/h15-16,19-20,22H,4-14H2,1-3H3/t16-,19+,20+,22-,23+,24+,25-/m1/s1

InChI key

MOFIIHQCTIJVBB-JEHIOXJOSA-N

Packaging

10, 25, 100 mg in glass bottle

Biochem/physiol Actions

RU 26752 is a mineralocorticoid receptor antagonist.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

3

Saaeha Rauz et al.
Investigative ophthalmology & visual science, 44(4), 1643-1651 (2003-03-27)
In peripheral sodium-transporting tissues, the serum- and glucocorticoid-regulated kinase (SGK) isoform-1 is an early corticosteroid target gene in the activation of epithelial sodium channels (ENaCs). Sodium transport across the human ocular nonpigmented and pigmented ciliary epithelial bilayer (NPE-PE) is essential...
M Mirshahi et al.
Biochemical and biophysical research communications, 270(3), 811-815 (2000-04-25)
PCR analysis and Western blotting revealed the expression of the mineralocorticoid receptor (MCR) and the epithelial sodium channel (ENaC) genes at the level of RNA, DNA, and protein in several leukemic cell lines, fibroblasts from human cornea, and epithelial cells...
Sanjay Rajagopalan et al.
The Medical clinics of North America, 87(2), 441-457 (2003-04-16)
Based upon the results of the RALES trial and accumulating evidence about the role of aldosterone and aldosterone receptor antagonism in various disease states, the authors anticipate that aldosterone receptor antagonists will become standard therapy, along with ACE inhibitors and...
A Souque et al.
The Journal of steroid biochemistry and molecular biology, 57(5-6), 315-321 (1996-03-01)
To investigate the role of sulfhydryl groups in the interaction of agonists and antagonists with the human mineralocorticoid receptor (hMR) the effect of methyl methanethiosulfonate (MMTS) on free and liganded-hMR was examined. hMR was expressed in insect cells (Sf9) using...
G Lazar et al.
Biochimica et biophysica acta, 1033(1), 41-48 (1990-01-29)
Cardiac cytosol from adrenalectomized rats was radiolabelled with 10 nM tritiated RU 26752, R 5020 or aldosterone, to saturate the mineralocorticoid receptor (MCR) in the presence of 1 microM RU 38486 to block the glucocorticoid and progestin receptors. Free steroids...

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