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R2156

Sigma-Aldrich

Relaxin-1 human

recombinant, expressed in E. coli, >95% (SDS-PAGE), lyophilized powder

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Synonym(s):
RLN1, RLXH1, Relaxin 1
CAS Number:
NACRES:
NA.26

biological source

human

Quality Level

recombinant

expressed in E. coli

Assay

>95% (SDS-PAGE)

form

lyophilized powder

mol wt

(Contains two disulfide-linked subunits: A chain ~2.8 kDa B chain ~3.3 kDa)

technique(s)

cell culture | mammalian: suitable

suitability

endotoxin tested

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... RLN1(6013)

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R2156

Relaxin-1 human

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SRP3069

IGF-I human

Activin A active human Animal-component free, recombinant, expressed in Nicotiana, >97% (SDS-PAGE)

Sigma-Aldrich

A4362

Activin A active human

recombinant

expressed in E. coli

recombinant

expressed in HEK 293 cells

recombinant

expressed in E. coli

recombinant

expressed in Nicotiana

assay

>95% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥95% (HPLC)

assay

>97% (SDS-PAGE)

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized

mol wt

(Contains two disulfide-linked subunits: A chain ~2.8 kDa B chain ~3.3 kDa)

mol wt

127.5 kDa (The protein migrates as a 140 kDa band on SDS-PAGE due to glycosylation.)

mol wt

~7.6 kDa

mol wt

27.4 kDa (disulfide-linked homodimers of two βA chains, each containing 116 amino residues)

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

General description

Cell signaling hormone that is prominent in the prostate, and belongs to the insulin superfamily

Biochem/physiol Actions

Relaxin 1 may function in regulating blood pressure, controlling heart rate, and releasing oxytocin and vasopressin
Relaxin has been shown to have antifibrotic effects in renal fibroblasts through mechanisms that increase collagenase activity and via TGF-β signaling.

Physical form

Lyophilized powder containing BSA

Reconstitution

In Phosphate buffered saline solution containing at least 0.1% serum albumin. The concentration should be ≥10 μg/mL

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Rosemary Masterson et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 19(3), 544-552 (2004-02-10)
Renal fibroblasts are important effector cells in tubulointerstitial fibrosis, with experimental antifibrotic strategies focusing on the functional down-regulation of these cells. Several experimental models of fibrosis have provided evidence for the effectiveness of the polypeptide hormone relaxin as a potential

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