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R3772

Sigma-Aldrich

Riluzole

Synonym(s):

2-Amino-6-(trifluoromethoxy)benzothiazole

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About This Item

Empirical Formula (Hill Notation):
C8H5F3N2OS
CAS Number:
1744-22-5
Molecular Weight:
234.20
MDL number:
MFCD00210213
UNSPSC Code:
12352204

SMILES string

Nc1nc2ccc(OC(F)(F)F)cc2s1

InChI

1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13)

InChI key

FTALBRSUTCGOEG-UHFFFAOYSA-N

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Biochem/physiol Actions

Glutamate release inhibitor

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
068H1057
039H0451
127H0714
058H1242

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Alessandra Cifra et al.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 19(2), 137-144 (2012-05-19)
Amyotrophic lateral sclerosis (Lou Gehrig's disease) is a devastating neurodegenerative disorder for which the only licensed treatment is riluzole. Although riluzole clinical efficacy is rather limited, its use has important implications for identifying those parameters that might improve its clinical
Charles Tzu-Chi Lee et al.
Journal of epidemiology, 23(1), 35-40 (2012-11-03)
Amyotrophic lateral sclerosis (ALS) is a rare disease in Taiwan; thus, estimation of ALS mortality is difficult. We evaluated factors associated with ALS survival in Taiwan. The study enrolled 1149 Taiwanese with a primary diagnosis of ALS during 1999-2008. Follow-up
B C Cheah et al.
Current medicinal chemistry, 17(18), 1942-1199 (2010-04-10)
Amyotrophic lateral sclerosis (ALS) is a universally fatal neurodegenerative disease of the human motor system. Aetiological mechanisms implicated in the development of ALS have been linked to the glutamatergic neurotransmitter system, with destruction of motor neurons triggered through excessive activation
Mark C Bellingham
Journal of neurophysiology, 110(5), 1047-1061 (2013-06-07)
Riluzole is the sole treatment for amyotrophic lateral sclerosis (ALS), but its therapeutically relevant actions on motor neurons are not well defined. Whole cell patch-clamp recordings were made from hypoglossal motor neurons (HMs, n = 25) in brain stem slices
Shahriar Koochekpour et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 18(21), 5888-5901 (2012-10-18)
During glutaminolysis, glutamine is catabolized to glutamate and incorporated into citric acid cycle and lipogenesis. Serum glutamate levels were measured in patients with primary prostate cancer or metastatic castrate-resistant prostate cancer (mCRPCa) to establish clinical relevance. The effect of glutamate
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