R7017

Sigma-Aldrich

Resazurin sodium salt

powder, BioReagent, suitable for cell culture

Synonym(s):
7-Hydroxy-3H-phenoxazin-3-one-10-oxide sodium salt
Empirical Formula (Hill Notation):
C12H6NNaO4
CAS Number:
Molecular Weight:
251.17
Beilstein/REAXYS Number:
3794971
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.75

Quality Level

product line

BioReagent

form

powder

composition

Dye content, ~80%

application(s)

cell culture | mammalian: suitable

pH range

3.8 - 6.5, orange to violet

solubility

H2O: soluble

λmax

600 nm

SMILES string

[Na+].[O-]c1ccc2c(OC3=CC(=O)C=CC3=[N+]2[O-])c1

InChI

1S/C12H7NO4.Na/c14-7-1-3-9-11(5-7)17-12-6-8(15)2-4-10(12)13(9)16;/h1-6,14H;/q;+1/p-1

InChI key

IVGPGQSSDLDOLH-UHFFFAOYSA-M

Looking for similar products? Visit Product Comparison Guide

Application

Resazurin sodium salt has been used in viability assay:
  • to measure cell viability of A. fumigatus
  • to assess cell proliferation
  • to determine A. fumigatus viability in high-throughput screenings of microbial natural extracts

For the measurement of metabolic activity and proliferation of living cells. The bioreduction of the dye reduces the amount of the oxidized form (blue) and concomitantly increases the fluorescent intermediate (red).

Packaging

1, 5 g in glass bottle

Biochem/physiol Actions

Resazurin is a blue, non-fluorescent dye originally used to test milk/biological fluids for bacterial and yeast contamination. It is also useful in sperm viability and semen quality test. Resazurin is applicable in cytotoxicity determination.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Sugandha Bhatia et al.
Journal of clinical medicine, 8(6) (2019-06-27)
Dynamic interconversions between transitional epithelial and mesenchymal states underpin the epithelial mesenchymal plasticity (EMP) seen in some carcinoma cell systems. We have delineated epithelial and mesenchymal subpopulations existing within the PMC42-LA breast cancer cell line by their EpCAM expression. These...
Expression of TweakR in breast cancer and preclinical activity of enavatuzumab, a humanized anti-TweakR mAb
Chao DT, et al.
Journal of Cancer Research and Clinical Oncology, 139, 315?325-315?325 (2012)
Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity
O Brien J, et al.
European Journal of Biochemistry, 267(17), 5421-5426 (2000)
Hitting the caspofungin salvage pathway of human-pathogenic fungi with the novel lasso peptide humidimycin (MDN-0010)
Valiante V, et al.
Antimicrobial agents and chemotherapy, 59(9), 5145-5153 (2015)
Julianna Siciliano de Araújo et al.
Antimicrobial agents and chemotherapy, 63(4) (2019-01-24)
More than 100 years after being first described, Chagas disease remains endemic in 21 Latin American countries and has spread to other continents. Indeed, this disease, which is caused by the protozoan parasite Trypanosoma cruzi, is no longer just a problem...

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

MilliporeSigma

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.