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R7382

Rifampicin

powder or crystals, suitable for plant cell culture, BioReagent

Synonym(s):

3-(4-Methylpiperazinyliminomethyl)rifamycin SV, Rifampin, Rifamycin AMP

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About This Item

Empirical Formula (Hill Notation):
C43H58N4O12
CAS Number:
13292-46-1
Molecular Weight:
822.94
NACRES:
NA.72
PubChem Substance ID:
24899391
UNSPSC Code:
10171502
EC Number:
236-312-0
MDL number:
MFCD00151389
Beilstein/REAXYS Number:
5723476

Key Documents

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Product Name

Rifampicin, suitable for plant cell culture, BioReagent, ≥95% (HPLC), powder or crystals

InChI key

JQXXHWHPUNPDRT-WLSIYKJHSA-N

InChI

1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1

SMILES string

CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(NC(=O)C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(\C=N\N5CCN(C)CC5)c(O)c4c3C2=O

product line

BioReagent

assay

≥95% (HPLC)

form

powder or crystals

technique(s)

cell culture | plant: suitable

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycobacteria

application(s)

agriculture

mode of action

protein synthesis | interferes

storage temp.

−20°C

Quality Level

200

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1 of 4

This Item
R0700000557303PHR1806
Rifampicin suitable for plant cell culture, BioReagent, ≥95% (HPLC), powder or crystals

Sigma-Aldrich

R7382

Rifampicin

Rifampicin European Pharmacopoeia (EP) Reference Standard

R0700000

Rifampicin

Rifampicin Antibiotic that specifically inhibits DNA-dependent RNA polymerase in bacteria by forming an inactive complex.

Sigma-Aldrich

557303

Rifampicin

Rifampin Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1806

Rifampin

mode of action

protein synthesis | interferes

mode of action

-

mode of action

-

mode of action

-

antibiotic activity spectrum

Gram-negative bacteria, mycobacteria, Gram-positive bacteria

antibiotic activity spectrum

-

antibiotic activity spectrum

-

antibiotic activity spectrum

-

technique(s)

cell culture | plant: suitable

technique(s)

-

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

product line

BioReagent

product line

-

product line

-

product line

-

Quality Level

200

Quality Level

-

Quality Level

100

Quality Level

300

application(s)

agriculture

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

pharmaceutical (small molecule)

General description

Chemical structure: macrolide

Application

Rifampicin, a rifamycin, is active against mycobacteria. Rifamycin, is also an inhibitor of chloroplast RNA polymerase and may be used to study chloroplast-level DNA transcription in plants.

Biochem/physiol Actions

Inhibits the assembly of DNA and protein into mature virus particles.
Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Product is sensitive to light and moisture. Store under inert gas.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000516082
0000516082
0000492958
0000492958
0000430822

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Stephan Eberhard et al.
The Plant journal : for cell and molecular biology, 31(2), 149-160 (2002-07-18)
We performed a systematic investigation of the quantitative relationship between genome copy number, transcription, transcript abundance and synthesis of photosynthetic proteins in the chloroplast of the green algae Chlamydomonas reinhardtii grown either in mixotrophic or phototrophic conditions. The chloroplast gene
Igor Gurevich et al.
Biology open, 9(12) (2020-12-04)
Non-alcoholic fatty liver disease (NAFLD) affects 30-40% of adults and 10% of children in the US. About 20% of people with NAFLD develop non-alcoholic steatohepatitis (NASH), which may lead to cirrhosis and liver cancer, and is projected to be a
Sandra V Kik et al.
The Journal of infectious diseases, 211 Suppl 2, S58-S66 (2015-03-15)
The potential available market (PAM) for new diagnostics for tuberculosis that meet the specifications of the high-priority target product profiles (TPPs) is currently unknown. We estimated the PAM in 2020 in 4 high-burden countries (South Africa, Brazil, China, and India)
Samy Figueiredo et al.
Antimicrobial agents and chemotherapy, 53(6), 2657-2659 (2009-03-25)
Two clonally related Acinetobacter baumannii isolates, A1 and A2, were obtained from the same patient. Isolate A2, selected after an imipenem-containing treatment, showed reduced susceptibility to carbapenems. This resistance pattern was related to insertion of the ISAba1 element upstream of
Laurent Poirel et al.
Antimicrobial agents and chemotherapy, 55(2), 934-936 (2010-12-01)
Seven carbapenem-resistant NDM-1-positive Klebsiella pneumoniae isolates were recovered from patients hospitalized between 2007 and 2009 in different wards at a referral and tertiary care center in Nairobi. Most of the isolates were obtained from urine. All isolates carried the bla(NDM-1)
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