RES0196M-B7

SAFC

MOPSO

PharmaGrade, Manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production, suitable for cell culture

Synonym(s):
MOPSO, 3-Morpholino-2-hydroxypropanesulfonic acid, β-Hydroxy-4-morpholinepropanesulfonic acid
Empirical Formula (Hill Notation):
C7H15NO5S
CAS Number:
Molecular Weight:
225.26
Beilstein/REAXYS Number:
1109697
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21
Pricing and availability is not currently available.

Quality Level

biological source

synthetic

Agency/Method

non-compendial

product line

PharmaGrade

form

powder

application(s)

cell culture | mammalian: suitable

useful pH range

6.2 - 7.6

pKa 

6.9

suitability

suitable for manufacturing use

foreign activity

Cytotoxicity, DNase, NICKase, RNase, and Protease; tested

SMILES string

OC(CN1CCOCC1)CS(O)(=O)=O

InChI

1S/C7H15NO5S/c9-7(6-14(10,11)12)5-8-1-3-13-4-2-8/h7,9H,1-6H2,(H,10,11,12)

InChI key

NUFBIAUZAMHTSP-UHFFFAOYSA-N

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General description

PharmaGrade products are manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. For more information on the PharmaGrade Program, visit sigma-aldrich.com/safc-pharmagrade.

Application

MOPSO is a biological buffer also referred to as a second generation “Good′s” buffer which displays improved solubility compared to traditional “Good′s” buffers. The pKa of MOPSO is 6.9 which make it an ideal candidate for buffer formulations which require a pH slightly below physiological to maintain a stable environment in solution. MOPSO is considered to be non-toxic to culture cell lines and provides high-solution clarity.

MOPSO can be used in cell culture media, biopharmaceutical buffer formulations (both upstream and downstream) and diagnostic reagents.

Packaging

Product is available in the following package sizes:
RES0196M-B701X: 100 gm container
RES0196M-B702X: 1 kg container
RES0196M-B704X: 10 kg container

Caution

According to Ferreira, et al., MOPSO can have a strong interaction with iron in solution. Based on this citation, it is recommended to use plastic-coated or PTFE-coated utensils when working with this chemical.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Target Organs

Respiratory system

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

(Un)suitability of the use of pH buffers in biological, biochemical and environmental studies and their interaction with metal ions ? a review.
Ferreira C.M.H. et al.
Royal Society of Chemistry Advances, 5, 30989-31003 (2015)
Annett Richter et al.
Planta, 241(6), 1351-1361 (2015-02-15)
Of the three functional FPPS identified in maize, fpps3 is induced by herbivory to produce FDP important for the formation of the volatile sesquiterpenes of plant defense. Sesquiterpenes are not only crucial for the growth and development of a plant...
Ryan J Smith et al.
Biophysical chemistry, 203-204, 12-21 (2015-05-23)
Poly(ethylene glycol) (PEG) is often conjugated to polyethylenimine (PEI) to provide colloidal stability to PEI-DNA polyplexes and shield charge leading to toxicity. Here, a library of nine cationic copolymers was synthesized by grafting three molecular weights (750, 2000, 5000Da) of...
Yasuyuki Nakamura et al.
Biotechnology and bioengineering, 112(9), 1906-1915 (2015-04-09)
The monoamine neurotransmitter serotonin (5-HT) regulates a wide spectrum of human physiology through the 5-HT receptor family. One such receptor, the 5-HT1A receptor (HTR1A), is the most widely studied subtype and represents a significant molecular target in medicinal and therapeutic...
Sven Amrhein et al.
Biotechnology and bioengineering, 112(12), 2485-2494 (2015-06-16)
The surface hydrophobicity of a protein is an important factor for its interactions in solution and thus the outcome of its production process. Yet most of the methods are not able to evaluate the influence of these hydrophobic interactions under...

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