RES0197M-A7

SAFC

MOPS sodium salt

PharmaGrade, Manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production, suitable for cell culture

Synonym(s):
3-(N-Morpholino)propanesulfonic acid sodium salt, 4-Morpholinepropanesulfonic acid sodium salt
Empirical Formula (Hill Notation):
C7H14NNaO4S
CAS Number:
Molecular Weight:
231.25
MDL number:
PubChem Substance ID:
NACRES:
NA.21
Pricing and availability is not currently available.

biological source

synthetic

Agency/Method

non-compendial

product line

PharmaGrade

form

powder

application(s)

cell culture | mammalian: suitable

impurities

Endotoxin and microbial, tested

useful pH range

6.5 - 7.9

pKa (25 °C)

7.2

suitability

suitable for manufacturing use

foreign activity

Cytotoxicity, DNase, NICKase, RNase, and Protease; tested

SMILES string

Na+.O-S(=O)(=O)CCCN1CCOCC1

InChI

1S/C7H15NO4S.Na/c9-13(10,11)7-1-2-8-3-5-12-6-4-8;/h1-7H2,(H,9,10,11);/q;+1/p-1

InChI key

MWEMXEWFLIDTSJ-UHFFFAOYSA-M

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General description

PharmaGrade products are manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. For more information on the PharmaGrade Program, visit sigma-aldrich.com/safc-pharmagrade.

Application

MOPS Sodium is a biological buffer also referred to as a “Propane Sultone” buffer. The pKa of MOPS Sodium is 7.01 which make it an ideal candidate for medias and protein based buffer formulations to maintain a stable environment in solution. MOPS Sodium is considered to be non-toxic to culture cell lines and provides high solution clarity.

MOPS Sodium is used in cell culture media, biopharmaceutical buffer formulations both upstream and downstream and diagnostic reagents. MOPS based buffers are used in purification bioprocesses of antibodies, peptides, proteins and blood components. MOPSO based buffers have been described for fixation of cells from urine samples.

Packaging

Product is available in the following package sizes:
RES0197M-A701X: 100g container
RES0197M-A702X 1kg container
RES0197M-A704X: 10kg container
RES0197M-A705X: 25kg container

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Ying Hou et al.
Biotechnology progress, 31(4), 974-982 (2015-05-29)
Protein A chromatography is widely employed for the capture and purification of monoclonal antibodies (mAbs). Because of the high cost of protein A resins, there is a significant economic driving force to seek new downstream processing strategies. Membrane chromatography has...

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