RES1000A-A7

SAFC

ACES

PharmaGrade, Manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production, suitable for cell culture

Synonym(s):
ACES, N-(2-Acetamido)-2-aminoethanesulfonic acid, N-(Carbamoylmethyl)taurine, N-(Carbamoylmethyl)-2-aminoethanesulfonic acid
Linear Formula:
H2NCOCH2NHCH2CH2SO3H
CAS Number:
Molecular Weight:
182.20
Beilstein/REAXYS Number:
2253770
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21
Pricing and availability is not currently available.

Quality Level

biological source

synthetic

Agency/Method

non-compendial

product line

PharmaGrade

form

powder

application(s)

cell culture | mammalian: suitable

impurities

Endotoxin and microbial; tested

useful pH range

6.1 - 7.5

pKa (25 °C)

6.8

mp

>220 °C (dec.) (lit.)

suitability

suitable for manufacturing use

foreign activity

Cytotoxicity, DNase, NICKase, RNase, and Protease; tested

SMILES string

NC(=O)CNCCS(O)(=O)=O

InChI

1S/C4H10N2O4S/c5-4(7)3-6-1-2-11(8,9)10/h6H,1-3H2,(H2,5,7)(H,8,9,10)

InChI key

DBXNUXBLKRLWFA-UHFFFAOYSA-N

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General description

PharmaGrade products are manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. For more information on the PharmaGrade Program, visit sigma-aldrich.com/safc-pharmagrade.

Application

ACES is a biological buffer often referred to as a “Good′s” buffer. The pKa of ACES is 6.8 which makes ACES a good candidate for a wide array for biological applications. ACES has been used primarily as a buffer in agarose and polyacrylamide gel electrophoresis separations as well as isoelectric focusing of proteins. ACES is highly water soluble and provides high-solution clarity.

Specific applications include buffers for cell culture media, protein separations and diagnostic reagent production.

Packaging

Product is available in the following package sizes:
RES1000A-A701X: 100 gm container
RES1000A-A702X: 1 kg container
RES1000A-A704X: 10 kg container

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Free metal ion depletion by "Good's" buffers. II. N-(2-acetamido)-2-aminoethanesulfonic acid (ACESH): complexes with calcium(II), magnesium(II), manganese(II), cobalt(II), zinc(II), nickel(II), and copper(II).
J M Pope et al.
Analytical biochemistry, 103(2), 214-221 (1980-04-01)
D J Chappell
Clinical chemistry, 31(8), 1384-1386 (1985-08-01)
The hereditary deficiency variants of alpha 1-antitrypsin that are associated with diseases such as emphysema are usually identified by use of isoelectric focusing on polyacrylamide gels. Agarose is a simpler, faster, safer, and more reliable medium for this, but resolution...
COMET challenges paradigm of ACE inhibition in mild heart failure.
Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners, 14(4), 207-208 (2003-11-19)
A Alonso
Electrophoresis, 10(7), 513-519 (1989-07-01)
The polymorphism of alpha-1-antitrypsin (PI) has been studied by hybrid isoelectric focusing in miniaturized immobilized pH gradient gels, with an interelectrode distance of 55 mm, in two narrow ranges of pH 4.35-4.75 and 4.35-4.55), following rehydration with pH 4.2-4.9 carrier...
P H Edelstein et al.
Journal of clinical microbiology, 31(12), 3329-3330 (1993-12-01)
Growth of Legionella spp. on buffered charcoal yeast extract medium supplemented with alpha-ketoglutarate and formulated with 3-(n-morpholino)propanesulfonic acid (MOPS), 3-(n-morpholino)-2-hydroxypropanesulfonic acid (MOPSO), or n-(2-acetamido)-2-aminoethanesulfonic acid (ACES) buffer was similar. With three exceptions, growth was no different in buffered yeast extract...

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