RES10070-A7

L-Asparagine monohydrate

Name: <SC>L</SC>-Asparagine monohydrate
Brand: SIGMA

Synonym(s):

(S)-(+)-2-Aminosuccinamic acid, (S)-2-Aminosuccinic acid 4-amide, L-Aspartic acid 4-amide

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About This Item

Linear Formula:

NH₂COCH₂CH(NH₂)COOH · H₂O

CAS Number:

5794-13-8

Molecular Weight:

150.13

EC Number:

200-735-9

UNSPSC Code:

12352209

NACRES:

NA.21

Beilstein/REAXYS Number:

1723527

MDL number:

MFCD00151038

Key Documents

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biological source

synthetic

assay

98.5-101.0% dry basis

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin and microbial, tested

Quality Level

400

InChI key

RBMGJIZCEWRQES-DKWTVANSSA-N

InChI

1S/C4H8N2O3.H2O/c5-2(4(8)9)1-3(6)7;/h2H,1,5H2,(H2,6,7)(H,8,9);1H2/t2-;/m0./s1

SMILES string

[H]O[H].N[C@@H](CC(N)=O)C(O)=O

mp

233-235 °C (lit.)

suitability

suitable for manufacturing use

foreign activity

Cytotoxicity, DNase, NICKase, RNase, and Protease; tested

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Bioprocessing & Formulation Raw Materials

Pharma & Biopharma Manufacturing

Upstream Process Chemicals

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This Item	A7094	A8381	A4284
SAFC RES10070-A7 L-Asparagine monohydrate	Sigma-Aldrich A7094 L-Asparagine monohydrate	Sigma-Aldrich A8381 L-Asparagine monohydrate	Sigma-Aldrich A4284 L-Asparagine monohydrate
biological source synthetic	biological source non-animal source	biological source synthetic	biological source synthetic
form powder	form powder	form powder	form powder
impurities endotoxin and microbial, tested	impurities endotoxin, tested	impurities -	impurities -
assay 98.5-101.0% dry basis	assay ≥98.0%	assay ≥99% (TLC)	assay ≥99% (TLC)
suitability suitable for manufacturing use	suitability -	suitability -	suitability -
foreign activity Cytotoxicity, DNase, NICKase, RNase, and Protease; tested	foreign activity -	foreign activity -	foreign activity -

General description

Our SAFC^® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.

Application

L-Asparagine is an essential amino acid. It is used as a cell culture media component and raw material for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.

Packaging

Product is available in the following package sizes:
RES10070-A701X: 100g container
RES10070-A702X: 1kg container
RES10070-A704X: 10kg container

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

comparable product

Product No.

Description

Pricing

137251

L-Asparagine monohydrate, EMPROVE^® EVOLVE

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Simultaneous determination of acrylamide, asparagine and glucose in food using short chain methyl imidazolium ionic liquid based ultrasonic assisted extraction coupled with analyte focusing by ionic liquid micelle collapse capillary electrophoresis.

Deia Abd El-Hady et al.

Food chemistry, 188, 551-558 (2015-06-05)

Acrylamide (AA) is a known lethal neurotoxin and carcinogen. AA is formed in foods during the browning process by the Maillard reaction of glucose (GL) with asparagine (AS). For the first time, the simultaneous online preconcentration and separation of AA

An analytical quality by design (aQbD) approach for a L-asparaginase activity method.

Han Yao et al.

Journal of pharmaceutical and biomedical analysis, 117, 232-239 (2015-09-18)

L-asparaginase is an effective anti-tumor agent for acute lymphoblastic leukemia. This work presents the development of an activity determination of L-ASNase preparations for pharmaceutical quality control purposes, in accordance with analytical Quality by Design principles. Critical method attributes, the absorbance

Influence of Free Amino Acids, Oligopeptides, and Polypeptides on the Formation of Pyrazines in Maillard Model Systems.

Gustavo Luis Leonardo Scalone et al.

Journal of agricultural and food chemistry, 63(22), 5364-5372 (2015-05-15)

Pyrazines are specific Maillard reaction compounds known to contribute to the unique aroma of many products. Most studies concerning the generation of pyrazines in the Maillard reaction have focused on amino acids, while little information is available on the impact

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