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RES1052B-B7

SAFC

BIOTIN

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Synonym(s):
Biotin, D-Biotin, Bios II, Coenzyme R, Vitamin B7, Vitamin H
Empirical Formula (Hill Notation):
C10H16N2O3S
CAS Number:
Molecular Weight:
244.31
Beilstein:
86838
EC Number:
MDL number:
NACRES:
NA.21

biological source

synthetic

Quality Level

Assay

97.5-100.5%

form

powder

impurities

Trace metals; tested

color

white

mp

231-233 °C (lit.)

suitability

suitable for manufacturing use

SMILES string

[H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=O)N2

InChI

1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1

InChI key

YBJHBAHKTGYVGT-ZKWXMUAHSA-N

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This Item
Y000197891827PHR1233
BIOTIN

SAFC

RES1052B-B7

BIOTIN

Biotin for system suitability European Pharmacopoeia (EP) Reference Standard

Y0001978

Biotin for system suitability

Biotin certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Supelco

91827

Biotin

Biotin Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1233

Biotin

assay

97.5-100.5%

assay

-

assay

-

assay

-

form

powder

form

solid

form

-

form

-

color

white

color

-

color

white

color

-

mp

231-233 °C (lit.)

mp

231-233 °C (lit.)

mp

231-233 °C (lit.)

mp

231-233 °C (lit.)

suitability

suitable for manufacturing use

suitability

-

suitability

-

suitability

-

General description

Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.
To request documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.

Packaging

Product is available in the following package sizes:
RES1052B-B701X: 1 g container
RES1052B-B707X: 10 g container
RES1052B-B708X: 25 g container

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Pierre-Alexandre Driguez et al.
Natural product reports, 31(8), 980-989 (2014-04-08)
Covering: up to November 2013. Heparin and heparan sulfate are natural polysaccharides with strong structural variations, which are responsible for their numerous specific biological properties. One key target of heparin, among others, is antithrombin, a serine protease inhibitor that, upon
Joseph R Burgoyne et al.
Methods in enzymology, 473, 281-303 (2010-06-02)
The recent development of robust methods for the detection of proteins susceptible to S-nitrosylation (RSNO) and sulfenation (RSOH) has provided greater insight into the role of these oxidative modifications in cell signaling. These techniques, which have been termed "biotin-switch" methods
Corey J Fugate et al.
Biochimica et biophysica acta, 1824(11), 1213-1222 (2012-02-14)
The enzyme cofactor and essential vitamin biotin is biosynthesized in bacteria, fungi, and plants through a pathway that culminates with the addition of a sulfur atom to generate the five-membered thiophane ring. The immediate precursor, dethiobiotin, has methylene and methyl
Abdussalam Adina-Zada et al.
Biochemical Society transactions, 40(3), 567-572 (2012-05-24)
The activity of the biotin-dependent enzyme pyruvate carboxylase from many organisms is highly regulated by the allosteric activator acetyl-CoA. A number of X-ray crystallographic structures of the native pyruvate carboxylase tetramer are now available for the enzyme from Rhizobium etli
Stéphane Mann et al.
Biochimica et biophysica acta, 1814(11), 1459-1466 (2010-12-25)
The four last steps of biotin biosynthesis, starting from pimeloyl-CoA, are conserved among all the biotin-producing microorganisms. Two enzymes of this pathway, the 8-amino-7-oxononanoate synthase (AONS) and the 7,8-diaminopelargonic acid aminotransferase (DAPA AT) are dependent on pyridoxal-5'-phosphate (PLP). This review

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