RES1164B-A7

SAFC

BIS-TRIS hydrochloride

PharmaGrade, Manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production., suitable for cell culture

Synonym(s):
2,2-Bis(hydroxymethyl)-2,2′,2″-nitrilotriethanol, BIS-TRIS hydrochloride, Bis(2-hydroxyethyl)aminotris(hydroxymethyl)methane, 2-Bis(2-hydroxyethyl)amino-2-(hydroxymethyl)-1,3-propanediol
Empirical Formula (Hill Notation):
C8H19NO5 · HCl
CAS Number:
Molecular Weight:
245.70
MDL number:
PubChem Substance ID:
NACRES:
NA.21
Pricing and availability is not currently available.

Quality Level

biological source

synthetic

Agency/Method

non-compendial

product line

PharmaGrade

form

powder

application(s)

cell culture | mammalian: suitable

impurities

Endotoxin and microbial; tested

useful pH range

5.8 - 7.2

pKa 

6.5

suitability

suitable for manufacturing use

foreign activity

Cytotoxicity, DNase, NICKase, RNase, and Protease; tested

SMILES string

Cl.OCCN(CCO)C(CO)(CO)CO

InChI

1S/C8H19NO5.ClH/c10-3-1-9(2-4-11)8(5-12,6-13)7-14;/h10-14H,1-7H2;1H

InChI key

VEYRVLHAMHQVTC-UHFFFAOYSA-N

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General description

PharmaGrade products are manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. For more information on the PharmaGrade Program, visit sigma-aldrich.com/safc-pharmagrade.

Application

Bis Tris HCl is a commonly used biological buffer for very broad usage in biological systems such as diagnostics, electrophoresis and protein based bioprocessing. The pKa of Bis Tris is 6.36, which makes it a good candidate for biological-based formulations.

Bis Tris HCl can be used in a wide variety of biological applications including culture media, electrophoresis separations and diagnostic reagent formulations.

Packaging

Product is available in the following package sizes:
RES1164B-A701X: 100 gm container
RES1164B-A702X: 1 kg container
RES1164B-A704X: 10 kg container

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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