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S0375

D-Saccharic acid 1,4-lactone monohydrate

≥98.0% (HPLC)

Synonym(s):

D-Glucaric acid-1,4-lactone, D-Saccharolactone

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About This Item

Empirical Formula (Hill Notation):
C6H8O7 · H2O
CAS Number:
Molecular Weight:
210.14
Beilstein/REAXYS Number:
85594
MDL number:
UNSPSC Code:
12352201
PubChem Substance ID:
NACRES:
NA.25

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assay

≥98.0% (HPLC)

form

powder

impurities

≤10.0% water (Karl Fischer)

color

white

mp

91 - 93 °C ((196 - 199 °F ))

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

2-8°C

SMILES string

O.O[C@@H]1[C@@H](O)C(=O)O[C@@H]1[C@H](O)C(O)=O

InChI

1S/C6H8O7.H2O/c7-1-2(8)6(12)13-4(1)3(9)5(10)11;/h1-4,7-9H,(H,10,11);1H2/t1-,2-,3+,4+;/m1./s1

InChI key

NPFKVZHSFSFLPU-QGBSHYGGSA-N

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1 of 4

This Item
85145079469L254
assay

≥98.0% (HPLC)

assay

≥99%

assay

≥97.0% (HPLC)

assay

-

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

solubility

water: soluble 25 mg/mL, clear, colorless

solubility

-

solubility

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

crystals

form

powder

storage temp.

2-8°C

storage temp.

-

storage temp.

−20°C

storage temp.

-

impurities

≤10.0% water (Karl Fischer)

impurities

-

impurities

-

impurities

dextrose, passes test, sucrose, passes test, ≤0.005% insolubles, 4.0-6.0% water

General description

D-Saccharic acid 1,4-lactone monohydrate (DSAL) has an ability to inhibit the activity of β-glucuronidase enzyme.[1]It also potentially inhibits Klotho deglycosylation of excitatory amino acid transporters (EAATs) and peptide transporters (PEPTs).[2]

Application

D-Saccharic acid 1,4-lactone monohydrate has been used as a constituent of phosphate buffer to block incidental β-glucuronidase activity in Streptococcus pneumoniae hyaluronan lyase (SpnHL) activity assay.[3] It has also been used as a component of reaction mixture in Iduronidase activity assay[4] and UDP-glucuronosyltransferase 1 (UGT1A1) inhibition assay.[5]

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Gertrud E Morlock et al.
Antioxidants (Basel, Switzerland), 10(1) (2021-01-21)
The antioxidative activity of Camelia sinensis tea and especially powdered tea extracts on the market, among others used as added value in functional foods, can considerably vary due to not only natural variance, but also adulteration and falsification. Thus, an
Cas9-mediated allelic exchange repairs compound heterozygous recessive mutations in mice
Wang D, et al.
Nature Biotechnology, 36(9), 839-839 (2018)
In vitro OATP1B1 and OATP1B3 inhibition is associated with observations of benign clinical unconjugated hyperbilirubinemia
Chiou W, et al.
Xenobiotica, 44(3), 276-282 (2014)
Magnetic macroporous bead cellulose functionalised with recombinant hyaluronan lyase for controllable hyaluronan fragmentation
Kavsparova J, et al.
Process Biochemistry (Oxford, United Kingdom), 72, 105-111 (2018)
Klotho preservation by Rhein promotes toll-like receptor 4 proteolysis and attenuates lipopolysaccharide-induced acute kidney injury
Bi F, et al.
Journal of Molecular Medicine, 96(9), 915-927 (2018)

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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