S0438

Anti-Sodium Channel PN4 antibody produced in rabbit

Name: Anti-Sodium Channel PN4 antibody produced in rabbit
Brand: SIGMA
Price: 334 USD

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-Sodium Channel Scn8a

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0.05 ML

$334.00

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD03455989

Conjugate:

unconjugated

Clone:

polyclonal

Application:

WB CL

Species reactivity:

rat

Citations:

Technique(s):

western blot (chemiluminescent): 1:200

Uniprot accession no.:

O88420

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

rat

technique(s)

western blot (chemiluminescent): 1:200

UniProt accession no.

O88420

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... SCN8A(6334)
mouse ... Scn8a(20273)
rat ... Scn8a(29710)

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Show Differences

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This Item	S0819	SAB2108709	WH0006335M1
Sigma-Aldrich S0438 Anti-Sodium Channel PN4 antibody produced in rabbit	Sigma-Aldrich S0819 Anti-Sodium Channel Na_V1.5 antibody produced in rabbit	Sigma-Aldrich SAB2108709 Anti-SCN8A	Sigma-Aldrich WH0006335M1 Monoclonal Anti-SCN9A antibody produced in mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form purified immunoglobulin
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
biological source rabbit	biological source rabbit	biological source rabbit	biological source mouse
clone polyclonal	clone polyclonal	clone polyclonal	clone 5A11, monoclonal
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

synthetic peptide corresponding to residues 1042-1061 of mouse or rat Scn8a (intracellular epitope). The peptide is highly homologous (19/20 residues identical) in human.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide.

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pictograms

GHS06,GHS09

signalword

Danger

hcodes

H302 + H332,H311,H411

pcodes

P273 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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The endogenous calpain inhibitor calpastatin attenuates axon degeneration in murine Guillain-Barré syndrome.

Rhona McGonigal et al.

Journal of the peripheral nervous system : JPNS, 28(1), 4-16 (2022-11-07)

Axon degeneration accounts for the poor clinical outcome in Guillain-Barré syndrome (GBS), yet no treatments target this key pathogenic stage. Animal models demonstrate anti-ganglioside antibodies (AGAb) induce axolemmal complement pore formation through which calcium flux activates the intra-axonal calcium-dependent proteases

Schwann cell nodal membrane disruption triggers bystander axonal degeneration in a Guillain-Barré syndrome mouse model.

Rhona McGonigal et al.

The Journal of clinical investigation, 132(14) (2022-06-08)

In Guillain-Barré syndrome (GBS), both axonal and demyelinating variants can be mediated by complement-fixing anti-GM1 ganglioside autoantibodies that target peripheral nerve axonal and Schwann cell (SC) membranes, respectively. Critically, the extent of axonal degeneration in both variants dictates long-term outcome.

The MMP-9/TIMP-1 axis controls the status of differentiation and function of myelin-forming Schwann cells in nerve regeneration.

Youngsoon Kim et al.

PloS one, 7(3), e33664-e33664 (2012-03-23)

Myelinating Schwann cells (mSCs) form myelin in the peripheral nervous system. Because of the works by us and others, matrix metalloproteinase-9 (MMP-9) has recently emerged as an essential component of the Schwann cell signaling network during sciatic nerve regeneration. In

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