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S101

(R)-(+)-SKF-38393 hydrochloride

≥98% (HPLC), solid

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About This Item

Empirical Formula (Hill Notation):
C16H17NO2 · HCl
CAS Number:
81702-42-3
Molecular Weight:
291.77
NACRES:
NA.77
PubChem Substance ID:
329824192
UNSPSC Code:
12352200
MDL number:
MFCD00055189

Key Documents

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Product Name

(R)-(+)-SKF-38393 hydrochloride, ≥98% (HPLC), solid

InChI

1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H/t14-;/m1./s1

SMILES string

Cl.Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O

InChI key

YEWHJCLOUYPAOH-PFEQFJNWSA-N

assay

≥98% (HPLC)

form

solid

optical activity

[α]22/D +16.1°, c = 1.2 in methanol(lit.)

storage condition

desiccated

color

off-white to light tan

solubility

0.1 M HCl: 1.2 mg/mL
ethanol: 3.4 mg/mL
H2O: 5 mg/mL
aqueous base: unstable

Quality Level

100

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Show Differences

1 of 4

This Item
D047D054L131
(R)-(+)-SKF-38393 hydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

S101

(R)-(+)-SKF-38393 hydrochloride

(±)-SKF-38393 hydrochloride crystalline, ≥98% (HPLC)

Sigma-Aldrich

D047

(±)-SKF-38393 hydrochloride

R(+)-SCH-23390 hydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

D054

R(+)-SCH-23390 hydrochloride

L-745,870 hydrochloride

Sigma-Aldrich

L131

L-745,870 hydrochloride

form

solid

form

crystalline

form

solid

form

solid

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

solubility

0.1 M HCl: 1.2 mg/mL, H2O: 5 mg/mL, ethanol: 3.4 mg/mL, aqueous base: unstable

solubility

H2O: >5 mg/mL, aqueous base: soluble (unstable)

solubility

H2O: >5 mg/mL

solubility

H2O: 0.2 mg/mL, ethanol: 1.4 mg/mL, 0.1 M HCl: 5.5 mg/mL

storage condition

desiccated

storage condition

desiccated, protect from light

storage condition

desiccated, protect from light

storage condition

-

color

off-white to light tan

color

white

color

white

color

white

Application

(R)-(+)-SKF-38393 hydrochloride has been used as a D1 dopamine receptor agonist to study its effect on the sleep-wake pattern of macaques rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).[1]

Biochem/physiol Actions

(R)-(+)-SKF-38393 hydrochloride is a D1 dopamine receptor agonist [1] and an active enantiomer of (±)-SKF-38393. It enhances pertussis toxin-insensitive and protein kinase A-mediated glutamate release in the hippocampal neurons.[2] SKF-38393, a benzazepine derivative,[3] exhibits anorectic effects.[4]

Disclaimer

Light sensitive

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Solutions may be stored for several days at 4 °C.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000283664
0000283664
020M4602V
0000140744
0000112565

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Carole Hyacinthe et al.
Neurobiology of disease, 63, 20-24 (2013-11-12)
Both excessive daytime sleepiness (EDS) and rapid eye movement (REM) sleep deregulation are part of Parkinson's disease (PD) non-motor symptoms and may complicate dopamine replacement therapy. We report here that dopamine agonists act differentially on sleep architecture in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C Kaiser et al.
Journal of medicinal chemistry, 25(6), 697-703 (1982-06-01)
Resolution of the unique dopamine receptor agonist 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine (1) was achieved by a stereospecific multistep conversion of the readily separated enantiomers of its O,O,N-trimethylated precursor 2. The absolute stereochemistry of the antipodes of 2-MeI was determined by single-crystal X-ray diffractometric
M R Zarrindast et al.
Pharmacology, 87(1-2), 85-89 (2011-01-19)
Both the dopamine receptor D(1) agonist SKF 38393 and the antagonist SCH 23390 are benzazepine derivatives that have been widely used as pharmacological tools and radioligands. Evidence suggests that behavioral effects of both compounds do not always correspond to their
Steven J Cooper et al.
European journal of pharmacology, 532(3), 253-257 (2006-02-16)
Free-feeding rats meet much of their daily energy requirements by consuming food in meals during the nocturnal phase of the night/day cycle. Meal pattern analysis methodology has been developed to record the patterns of meal taken over a 24-h period
A Bouron et al.
Neuroscience, 94(4), 1063-1070 (2000-01-07)
The present study was undertaken to better assess the role of dopamine on exocytosis. Since direct activation of adenylate cyclase (e.g., with forskolin) enhances neurotransmitter release it was of interest to see whether the activation of D1-type dopamine receptors, which
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