S1129

Succinyl coenzyme A sodium salt

≥85%

• Synonym(s): Succinyl CoA sodium salt
• Empirical Formula (Hill Notation): C₂₅H₄₀N₇O₁₉P₃S
• CAS Number: 108347-97-3
• Molecular Weight: 867.61
• PubChem Substance ID: 24899460

Properties

• Quality Level: 200
• assay: ≥85%
• form: powder
• solubility: water: 50 mg/mL, clear, colorless
• storage temp.: −20°C
• SMILES string: [Na+].[Na+].CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC([O-])=O

Description

Application

Succinyl coenzyme A sodium salt has been used:

• for the nonenzymatic succinylation of lysine in vitro,
• as a substrate for adipic acid biosynthesis in recombinant E. coli
• in isocitrate dehydrogenase (ICDH) treatment for the succinylation of proteins
• as a substrate to study the specificity and kinetics of enzymes such as acetate:succinate CoA-transferase and 5-aminolevulinate synthase (ALA synthase)

Packaging

5, 10, 25, 100 mg

Biochem/physiol Actions

Succinyl CoA is an intermediate in the citric acid cycle. It is formed by α-ketoglutarate dehydrogenase by the decarboxylation of α-ketoglutarate. Succinyl CoA is also formed from propionyl CoA during the β-oxidation of odd-chain fatty acids. Succinyl CoA serves as a precursor in heme synthesis. It is also required for the oxidation of ketone bodies.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315 - H319 - H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves