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S1437

Sigma-Aldrich

Sex Hormone-Binding Globulin from human serum

≥95% (SDS-PAGE), buffered aqueous glycerol solution

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Synonym(s):
SHBG, Testosterone-estradiol binding globulin
MDL number:
NACRES:
NA.32

biological source

human serum

Quality Level

Assay

≥95% (SDS-PAGE)

form

buffered aqueous glycerol solution

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... SHBG(6462)

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This Item
RAB0734T9265A9511
assay

≥95% (SDS-PAGE)

assay

-

assay

-

assay

≥97% (agarose gel electrophoresis)

form

buffered aqueous glycerol solution

form

-

form

lyophilized powder

form

lyophilized powder

technique(s)

cell culture | mammalian: suitable

technique(s)

ELISA: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

ELISA: suitable, tissue culture: suitable, western blot: suitable

UniProt accession no.

P04278

UniProt accession no.

-

UniProt accession no.

P01222, P16473

UniProt accession no.

P02768

shipped in

dry ice

shipped in

wet ice

shipped in

ambient

shipped in

-

General description

Sex hormone binding globulin (SHBG) is secreted by the liver. It is also expressed in the endometrium, ovary and testis. SHBG is composed of 402 amino acids and the gene encoding it is localized on human chromosome 17p12–p13.

Application

Sex hormone binding globulin (SHBG) from human serum has been used as a spiked sample in radioimmunoassay. It may also be used to study the effects of hydroxylated estrogen metabolites (2-OH-E2 and 4-OH-E2) on the mRNA and protein expression of SHBG in MCF-7 human breast cancer cell line.

Biochem/physiol Actions

Sex hormone binding globulin (SHBG) is a dimeric plasma glycoprotein with high affinity for the gonadal steroids, testosterone and estradiol. It regulates the availability of sex steroid hormones and limits their access to target cells. SHBG also inhibits estradiol-induced proliferation of breast cancer cells. Alterations in the expression of the protein have been linked to male infertility.

Physical form

Solution in 20 mM Tris-HCl, 10% Glycerol, pH 7.4

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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The ability of hydroxylated estrogens (2-OH-E2 and 4-OH-E2) to increase
of SHBG gene, protein expression and intracellular levels in MCF-7 cells
line
Gregoraszczuk EL
Endocrine regulations (2011)
Correlation between SHBG gene polymorphism and male infertility in Han population of Henan province of China
A STROBE-compliant article
Yuan-rong Cui
Medicine (2017)
Sex Hormone-Binding Globulin (SHBG), estradiol and breast cancer.
Fortunati N
Molecular and Cellular Endocrinology (2010)
Developmental time course of estradiol, testosterone, and dihydrotestosterone levels in discrete regions of male and female rat brain
Konkle ATM and McCarthy MM
Endocrinology, 152(1), 223-235 (2011)

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