S1542

Sigma-Aldrich

Anti-Substance P antibody produced in rabbit

whole antiserum

Synonym(s):
Anti-SP
MDL number:
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

whole antiserum

antibody product type

primary antibodies

clone

polyclonal

contains

15 mM sodium azide

species reactivity

cat, pig, human, bovine, monkey, rat

application(s)

dot blot: 1:20,000
radioimmunoassay: 1:5,000

conjugate

unconjugated

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... TAC1(6863)
rat ... Tac1(24806)

General description

Substance P (SP) is widely distributed throughout the central nervous system (CNS) and peripheral nervous system, including the brain, spinal cord, primary sensory neurons and intrinsic nerve fibers associated with the gastrointestinal (GI) tract.
Substance P (SP) is a 11 amino acid peptide. It is a member of tachykinins family, that includes neurokinin A, neurokinin B, neuropeptide K, neuropeptide Y and hemokinin-1 It is located on human chromosome 7q21.3.

Immunogen

synthetic Substance P (SP), conugated to KLH.

Application

Anti-Substance P antibody has been used in immunostaining and immunohistochemistry.

Biochem/physiol Actions

Substance P (SP) improves the multiplication and paracrine ability of stem cells acquired from adipose in vitro. It participates in the movement of several organ tracts, trigger glandular secretion and controls autonomic reflexes. It plays an important role in neuroimmune and systemic autoimmune/inflammatory conditions like multiple sclerosis (MS), rheumatoid arthritis, inflammatory bowel disease and also in infections and cancer.
Substance P (SP) is a neurotransmitter or neuromodulator. SP mediates the process of neurogenic inflammation.

Analysis Note

The antiserum is evaluated for activity and specificity by dot blot immunoassay and RIA.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Substance P enhances proliferation and paracrine potential of adipose-derived stem cells in vitro
Kim S, et al.
Biochemical and Biophysical Research Communications, 485(1), 131-113 (2017)
Reciprocal Regulation of Substance P and IL-12/IL-23 and the Associated Cytokines, IFN?/IL-17: A Perspective on the Relevance of This Interaction to Multiple Sclerosis
Vilisaar J, et al.
Journal of Neuroimmune Pharmacology, 10(3), 457-467 (2015)
Substance P mediates inflammatory oedema in acute pancreatitis via activation of the neurokinin-1 receptor in rats and mice
Grady EF, et al.
British Journal of Pharmacology, 130(3), 505-512 (2000)
Uniaxial mechanical strain modulates the differentiation of neural crest stem cells into smooth muscle lineage on micropatterned surfaces
Li X, et al.
PLoS ONE, 6(10) (2011)
Delineation of a de novo 7q21.3q31.1 Deletion by CGH-SNP Arrays in a Girl with Multiple Congenital Anomalies Including Severe Glaucoma
Martinez-Jacobo L, et al.
Molecular Syndromology, 4(6), 285-291 (2013)

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