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S1688

SR 57227A

solid

Synonym(s):

4-amino-1-(6-chloro-2-pyridyl)-piperidine hydrochloride

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5 MG

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About This Item

Empirical Formula (Hill Notation):
C10H14ClN3 · HCl
CAS Number:
77145-61-0
Molecular Weight:
248.15
MDL number:
MFCD01756430
UNSPSC Code:
12352200
PubChem Substance ID:
24278109
NACRES:
NA.77

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form

solid

Quality Level

100

color

white

solubility

H2O: soluble 9 mg/mL

SMILES string

Cl.NC1CCN(CC1)c2cccc(Cl)n2

InChI

1S/C10H14ClN3.ClH/c11-9-2-1-3-10(13-9)14-6-4-8(12)5-7-14;/h1-3,8H,4-7,12H2;1H

InChI key

FUMINTAAUJUVMP-UHFFFAOYSA-N

Gene Information

human ... HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242)

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This Item
SML1882R1402J3770
SR 57227A solid

Sigma-Aldrich

S1688

SR 57227A

RS 67333 hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML1882

RS 67333 hydrochloride

Raloxifene hydrochloride solid

Sigma-Aldrich

R1402

Raloxifene hydrochloride

JNJ7777120 ≥98% (HPLC)

Sigma-Aldrich

J3770

JNJ7777120

form

solid

form

powder

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

solubility

H2O: soluble 9 mg/mL

solubility

H2O: 1 mg/mL, clear (warmed)

solubility

DMSO: soluble 28 mg/mL, H2O: insoluble

solubility

DMSO: >20 mg/mL, H2O: insoluble

color

white

color

white to beige

color

light yellow

color

white to off-white

Gene Information

human ... HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242)

Gene Information

-

Gene Information

human ... ESR2(2100)

Gene Information

-

Application

SR 57227A may be used in 5-HT3-mediated cell signaling studies.

Biochem/physiol Actions

Potent and selective 5-HT3 serotonin receptor agonist.
SR 57227A is a highly selective of central and peripheral 5-HT3 receptors[1] and an inhibitor of NMDA receptor-mediated responses in rat cortical pyramidal cells.[2] It exhibits anti-depressant like effects in rats and decreased isolation-induced aggressive behavior.[3]

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
0000467015
0000467015
035M4605V
054M4616V
125K46053

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Takahiro Hayashi et al.
Neuroscience research, 66(1), 22-29 (2009-09-22)
The serotonin type 3 (5-HT(3)) receptor is an only ligand-gated ion channel among 14 serotonin receptors. Here, we examined the roles of the 5-HT(3) receptor in the formation of dendrites and axons, using a dissociation culture of embryonic rat cerebral
Z H Gui et al.
Neuroscience, 169(3), 1315-1325 (2010-06-26)
In the present study, we examined changes in the firing rate and firing pattern of putative slow-spiking (SS) and fast-spiking (FS) interneurons in medial prefrontal cortex (mPFC) and the effect of 5-hydroxytryptamine-3 (5-HT(3)) receptor agonist SR 57227A on the neuronal
J Y Zhang et al.
Neuropharmacology, 33(3-4), 483-491 (1994-03-01)
The techniques of extracellular single cell recording and microiontophoresis were used to study the effect of 5-HT3 receptor agonists on glutamate-activated firing of CA1 hippocampal pyramidal cells. Iontophoretic application of 5-HT3 receptor agonists 2-methyl-5-HT and SR 57227A produced a current
L Staner et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 11(4), 301-305 (2001-09-05)
The respective role of various classes of central serotonin (5-HT) receptors in the regulation of sleep-wakefulness cycles has been the subject of many studies. Notably, it has been reported that 5-HT1A/B receptors are involved in the regulation of rapid eye
Heba Abdel-Aziz et al.
European journal of pharmacology, 530(1-2), 136-143 (2005-12-21)
Ginger (rhizomes of Zingiber officinale) has been shown to exert potent anti-emetic properties, but its mode of action has not yet been elucidated. Among its active constituents, [6]-, [8]- and [10]-gingerol as well as [6]-shogaol were shown in different in
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