S4443

SCH-28080

Name: SCH-28080
Brand: SIGMA
Price: 245 USD
Availability: InStock

≥98% (HPLC), gastric H+ and K+-ATPase inhibitor, solid

Synonym(s):

2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₅N₃O

CAS Number:

76081-98-6

Molecular Weight:

277.32

MDL number:

MFCD00834620

UNSPSC Code:

12352200

PubChem Substance ID:

24278810

NACRES:

NA.77

Key Documents

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Product Name

SCH-28080, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

white to light tan

solubility

DMSO: soluble >10 mg/mL
H₂O: insoluble

compatibility

for use with ABI 7700

storage temp.

−20°C

SMILES string

Cc1nc2c(OCc3ccccc3)cccn2c1CC#N

InChI

1S/C17H15N3O/c1-13-15(9-10-18)20-11-5-8-16(17(20)19-13)21-12-14-6-3-2-4-7-14/h2-8,11H,9,12H2,1H3

InChI key

PYKJFEPAUKAXNN-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

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Show Differences

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This Item	SML1200	A9227	SML2462
Sigma-Aldrich S4443 SCH-28080	Sigma-Aldrich SML1200 RO8191	Sigma-Aldrich A9227 ABT-491 hydrochloride	Sigma-Aldrich SML2462 HZ-166
form solid	form powder	form solid	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level -
storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: soluble >10 mg/mL, H₂O: insoluble	solubility DMSO: 0.5 mg/mL, clear (warmed)	solubility H₂O: freely soluble 22 mg/mL	solubility DMSO: 2 mg/mL, clear
color white to light tan	color white to beige	color white to beige	color white to beige

Application

SCH-28080 was used to treat zebrafish embryos to study the role of H⁺/K⁺-ATPase in establishment of left-right axis during development.[1]

Biochem/physiol Actions

SCH-28080 is a potent inhibitor of gastric H+ and K+-ATPase. The novel antiulcer agents, SCH-28080 and SCH-32651 were examined for their ability to inhibit the H+K+ ATPase enzyme activity in a preparation of microsomal membranes from rabbit fundic mucosa. SCH- 28080 inhibited the isolated enzyme activity with a potency similar to omeprazole, IC₅₀s of 2.5 and 4.0 μM respectively. SCH 32651 was less potent exhibiting an IC₅₀ of 200.0 μM. Both compounds may therefore exert their antisecretory activity via a direct inhibition of the parietal cell H+K+ ATPase.

SCH-28080 is a potent inhibitor of gastric H⁺and K⁺-ATPase.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Pharmacological profiles of the murine gastric and colonic H,K-ATPases.

Jiahong Shao et al.

Biochimica et biophysica acta, 1800(9), 906-911 (2010-07-03)

The H,K-ATPase, consisting of α and ß subunits, belongs to the P-type ATPase family. There are two isoforms of the α subunit, HKα₁ and HKα₂ encoded by different genes. The ouabain-resistant gastric HKα₁-H,K-ATPase is Sch28080-sensitive. However, the colonic HKα₂-H,K-ATPase from

Characteristics of the K+-competitive H+,K+-ATPase inhibitor AZD0865 in isolated rat gastric glands.

P Kirchhoff et al.

American journal of physiology. Gastrointestinal and liver physiology, 291(5), G838-G843 (2006-06-27)

The gastric H+,K+-ATPase of the parietal cell is responsible for acid secretion in the stomach and is the main target in the pharmacological treatment of acid-related diseases. Omeprazole and other benzimidazole drugs, although having delayed efficacy if taken orally, have

Heterogeneity of H-K-ATPase-mediated acid secretion along the mouse collecting duct.

I Jeanette Lynch et al.

American journal of physiology. Renal physiology, 298(2), F408-F415 (2009-11-20)

In the collecting duct (CD), H-K-ATPases function in cation reabsorption and H secretion. This study evaluated H-K-ATPase-mediated H secretion along the mouse CD, measured as EIPA- and luminal bafilomycin A(1)-insensitive intracellular pH (pH(i)) recovery from acute H loading (NH(4)) using

The human non-gastric H,K-ATPase has a different cation specificity than the rat enzyme.

Herman G P Swarts et al.

Biochimica et biophysica acta, 1768(3), 580-589 (2006-12-02)

The primary sequence of non-gastric H,K-ATPase differs much more between species than that of Na,K-ATPase or gastric H,K-ATPase. To investigate whether this causes species-dependent differences in enzymatic properties, we co-expressed the catalytic subunit of human non-gastric H,K-ATPase in Sf9 cells

Inhibition of H+K+ATPase by SCH 28080 and SCH 32651.

C K Scott et al.

European journal of pharmacology, 112(2), 268-270 (1985-06-07)

The novel antiulcer agents, SCH 28080 and SCH 32651 were examined for their ability to inhibit the H+K+ ATPase enzyme activity in a preparation of microsomal membranes from rabbit fundic mucosa. SCH 28080 inhibited the isolated enzyme activity with a

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