S5321

S15535

≥98% (HPLC), solid

• Synonym(s): 1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-4-(2,3-dihydro-1h-inden-2-yl)-piperazine
• Empirical Formula (Hill Notation): C₂₁H₂₄N₂O₂
• CAS Number: 146998-34-7
• Molecular Weight: 336.43
• MDL number: MFCD00911672
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824452
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• color: white
• solubility: DMSO: ~6 mg/mL; H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: C1COc2c(O1)cccc2N3CCN(CC3)C4Cc5ccccc5C4
• InChI: 1S/C21H24N2O2/c1-2-5-17-15-18(14-16(17)4-1)22-8-10-23(11-9-22)19-6-3-7-20-21(19)25-13-12-24-20/h1-7,18H,8-15H2
• InChI key: QJPPEMXOOWNICQ-UHFFFAOYSA-N

Description

Application

S15535 has been used as a serotonin 1A receptor (5-HT1A) agonist in zebrafish.[1]

S15535 may be used in histamine 5-HT_1A-medaited cell signaling studies.

Biochem/physiol Actions

Potent, orally active, partial 5-HT_1A receptor agonist

S15535, a benzodioxane, is a selective but partial agonist of histamine serotonin 1A (5-HT_1A) receptor. It activates presynaptic 5-HT_1A receptors and suppresses the release of hippocampal 5-HT. It acts as an anxiolytic agent and modulates the cholinergic and cognitive function in rodents.[2]

Safety Information

• pictograms: GHS09
• signalword: Warning
• hcodes: H410
• pcodes: P273 - P391 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves