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S5567

Sigma-Aldrich

SP600125

≥98% (HPLC)

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Synonym(s):
1,9-Pyrazoloanthrone, Anthrapyrazolone
Empirical Formula (Hill Notation):
C14H8N2O
CAS Number:
129-56-6
Molecular Weight:
220.23
EC Number:
204-955-6
MDL number:
MFCD00022289
UNSPSC Code:
12352200
PubChem Substance ID:
24278395
NACRES:
NA.77

Quality Level

200

assay

≥98% (HPLC)

color

yellow

solubility

DMSO: 20 mg/ml, clear to very slightly hazy, faintly yellow to yellow
H2O: insoluble

storage temp.

2-8°C

SMILES string

O=C1c2ccccc2-c3n[nH]c4cccc1c34

InChI

1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)

InChI key

ACPOUJIDANTYHO-UHFFFAOYSA-N

Gene Information

human ... JUN(3725) , MAPK10(5602) , MAPK9(5601)

Application

C2C12 myoblasts were treated with SP600125 to test the stimulation of myogenesis.11 It was used to treat HepG2 cells to test the effects on oxysterol-induced necrosis.12

Biochem/physiol Actions

SP600125 is an anthrapyrazolone inhibitor of JNK that competes with ATP to inhibit the phosphorylation of c-Jun. It prevents the activation of inflammatory genes such as COX-2, IL-2 IFN-γ and TNF-α.8,9 It prevents the activation of JNK after brain ischemia and may be effective in treatment of ischemic stroke.10
A novel and selective inhibitor of c-Jun N-terminal kinase (JNK)

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Chenglu Peng et al.
Journal of agricultural and food chemistry, 67(32), 9009-9021 (2019-07-19)
Soybean allergy is a serious health risk to humans and animals; β-conglycinin is the primary antigenic protein in soybean. Intestinal porcine epithelial (IPEC-J2) cells were used as an in vitro physiological model of the intestinal epithelium to study the effects
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Following central nervous system injury in mammals, failed axonal regeneration is closely related to dysneuria. Previous studies have shown that the obvious effects of apolipoprotein E (ApoE) on traumatic brain injury (TBI) were associated with an axonal mechanism. However, little
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The JNK inhibitor SP600125 strongly inhibits cell proliferation in many human cancer cells by blocking mitosis progression and inducing cell death. Despite, all this study, the mechanism by which SP600125 inhibits mitosis-related effects in human cervical cells (HeLa cells) remains
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