S5921

Staurosporine from Streptomyces sp.

for molecular biology, ≥95% (HPLC)

• Synonym(s): staurosporine, Antibiotic AM-2282, protein kinase c inhibitor
• Empirical Formula (Hill Notation): C₂₈H₂₆N₄O₃
• CAS Number: 62996-74-1
• Molecular Weight: 466.53
• Beilstein/REAXYS Number: 1060573
• MDL number: MFCD00077402
• PubChem Substance ID: 24899680
• NACRES: NA.77

Properties

• Quality Level: 300
• grade: for molecular biology
• assay: ≥95% (HPLC)
• Mode of action: enzyme | inhibits
• antibiotic activity spectrum: fungi
• storage temp.: 2-8°C
• SMILES string: CN[C@@H]1C[C@@H]2O[C@@](C)([C@@H]1OC)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
• InChI: 1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20?,26-,28+/m1/s1
• InChI key: HKSZLNNOFSGOKW-ZGQXJOJZSA-N

Description

General description

Chemical structure: indol derivative

Application

Staurosporine from Streptomyces sp. was used to induce cell death in MDCK, 293T, Vero, HeLa, and Swiss Webster primary macrophage cells.⁵ It was used to study the effect of caspase activation on human sperm quality.⁶

Packaging

0.1, 0.5, 1 mg in serum bottle

Biochem/physiol Actions

Partially reverses MDR, sensitizing cells with MDR phenotype to cytotoxic agents. Inhibits Pgp phosphorylation. However, functional significance of Pgp phosphorylation is ill defined.

Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells.

Features and Benefits

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Analysis Note

Tested for inhibition of interleukin 2 production in Jurkat cells.

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H340 - H350 - H361d - H413
• Precautionary Statements: P201 - P202 - P273 - P280 - P308 + P313 - P405
• Personal Protective Equipment: dust mask type N95 (US),Eyeshields,Gloves
• RIDADR: NONH for all modes of transport
• WGK Germany: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable